Latency of multifocal visual evoked potentials in nonoptic neuritis eyes of multiple sclerosis patients associated with optic radiation lesions

The aim of the study was to test the hypothesis that latency delay of multifocal visual evoked potentials (mfVEP) in nonoptic neuritis (NON) eyes of multiple sclerosis (MS) patients is related to retrochiasmal demyelinating lesions. A total of 57 MS patients with no history of optic neuritis at leas...

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Veröffentlicht in:Investigative ophthalmology & visual science Jg. 55; H. 6; S. 3758
Hauptverfasser: Alshowaeir, Daniah, Yiannikas, Con, Garrick, Raymond, Parratt, John, Barnett, Michael H, Graham, Stuart L, Klistorner, Alexander
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 15.05.2014
Schlagworte:
Adult
Diffusion Tensor Imaging - methods
Evoked Potentials, Visual - physiology
Female
Humans
Image Processing, Computer-Assisted
Male
Multiple Sclerosis - complications
Multiple Sclerosis - diagnosis
Multiple Sclerosis - physiopathology
Neuritis - diagnosis
Neuritis - etiology
Neuritis - physiopathology
Optic Nerve - pathology
Optic Nerve - radiation effects
latency delay
optic radiation
multiple sclerosis
multifocal VEP
ISSN:1552-5783, 1552-5783
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Zusammenfassung:The aim of the study was to test the hypothesis that latency delay of multifocal visual evoked potentials (mfVEP) in nonoptic neuritis (NON) eyes of multiple sclerosis (MS) patients is related to retrochiasmal demyelinating lesions. A total of 57 MS patients with no history of optic neuritis at least in one eye, and 25 age- and sex-matched healthy controls was enrolled. Probabilistic tractography was used to reconstruct optic radiation (OR) fibers. The MS lesion volume within and outside of OR was calculated. Diffusion tensor imaging (DTI) indices were measured along OR fibers. The relationship of the mfVEP latency with OR lesions and DTI indices was examined. Average mfVEP latency in the MS cohort was significantly delayed compared to controls (P < 0.0001). Of the patients, 77% demonstrated OR lesions. Axial, radial, and mean diffusivity were significantly abnormal in MS patients (P < 0.001). Partial correlation demonstrated significant association between mfVEP latency delay and OR lesion load. There was also significant correlation between MfVEP latency and OR DTI. Subgroup analysis revealed significantly higher correlations in patients without a history of ON in either eye compared to the fellow eye of patients with previous ON. The findings of this study support our hypothesis that latency delay of the mfVEP in eyes of MS patients without previous ON is related to retrogenicular demyelinating lesions. Additionally, this study demonstrated that a previous episode of ON in the fellow eye may be a significant confounding factor, masking the relationship between the latency and OR lesions.
Bibliographie:ObjectType-Article-1
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ISSN:1552-5783
1552-5783
DOI:10.1167/iovs.14-14571