Lupin seed hydrolysate promotes G-protein-coupled receptor, intracellular Ca2+ and enhanced glycolytic metabolism-mediated insulin secretion from BRIN-BD11 pancreatic beta cells

Lupin seed proteins have been reported to exhibit hypoglycaemic effects in animals and humans following oral administration, however little is known about its mechanism of action. This study investigated the signalling pathway(s) responsible for the insulinotropic effect of the hydrolysate obtained...

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Bibliographic Details
Published in:	Molecular and cellular endocrinology Vol. 480; pp. 83 - 96
Main Authors:	Tapadia, Mrunmai, Carlessi, Rodrigo, Johnson, Stuart, Utikar, Ranjeet, Newsholme, Philip
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 15.01.2019
Subjects:	adenosine triphosphate calcium digestive enzymes dose response functional foods G-protein coupled receptors glucose glycemic effect glycolysis Gαq protein humans hydrolysates Hypoglycaemic insulin secretion Insulinotropic islets of Langerhans Lupin Lupinus angustifolius mechanism of action noninsulin-dependent diabetes mellitus Nutraceutical oral administration phospholipase C potassium channels potassium chloride protein kinase C seed extracts signal transduction β-Cells OPA 2-NBDG GTP DH KRBB DMSO PLC E:Ex FCCP cAMP K-ATP RIPA phosphatidylinositol 4 GDP CREB FSC SSC AC Hypoglycaemic GLP-1 β-Cells Nutraceutical T2D PKA TBST Lupin PKC DAG IP3 ECAR SEC MWCO Insulinotropic EPAC2 CRE GSIS AMPK GPCR PI Gαq protein OCR GLP-1R MCT
ISSN:	0303-7207, 1872-8057, 1872-8057
Online Access:	Get full text
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