Protein targeting by the itaconate family in immunity and inflammation

Immune cells are metabolically plastic and respond to inflammatory stimuli with large shifts in metabolism. Itaconate is one of the most up-regulated metabolites in macrophages in response to the gram negative bacterial product LPS. As such, itaconate has recently been the subject of intense researc...

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Bibliographic Details

Published in:	Biochemical journal Vol. 479; no. 24; p. 2499
Main Authors:	Day, Emily A, O'Neill, Luke A J
Format:	Journal Article
Language:	English
Published:	England 22.12.2022
Subjects:	Animals Inflammation - drug therapy Inflammation - metabolism Kelch-Like ECH-Associated Protein 1 - metabolism Mice NF-E2-Related Factor 2 - metabolism Succinates - metabolism Succinates - pharmacology infection itaconate post-translational modification immunometabolism inflammation
ISSN:	1470-8728, 1470-8728
Online Access:	Get more information
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