Protein targeting by the itaconate family in immunity and inflammation

Immune cells are metabolically plastic and respond to inflammatory stimuli with large shifts in metabolism. Itaconate is one of the most up-regulated metabolites in macrophages in response to the gram negative bacterial product LPS. As such, itaconate has recently been the subject of intense researc...

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Veröffentlicht in:	Biochemical journal Jg. 479; H. 24; S. 2499
Hauptverfasser:	Day, Emily A, O'Neill, Luke A J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 22.12.2022
Schlagworte:	Animals Inflammation - drug therapy Inflammation - metabolism Kelch-Like ECH-Associated Protein 1 - metabolism Mice NF-E2-Related Factor 2 - metabolism Succinates - metabolism Succinates - pharmacology infection itaconate post-translational modification immunometabolism inflammation
ISSN:	1470-8728, 1470-8728
Online-Zugang:	Weitere Angaben
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