Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

Mitochondrial abnormalities have been identified as a central mechanism in multiple neurodegenerative diseases and, therefore, the mitochondria have been explored as a therapeutic target. This review will focus on the evidence for mitochondrial abnormalities in the two most common neurodegenerative...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biochemical Society transactions Jg. 46; H. 4; S. 891
Hauptverfasser: Macdonald, Ruby, Barnes, Katy, Hastings, Christopher, Mortiboys, Heather
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 20.08.2018
Schlagworte:
Alzheimer Disease - drug therapy
Alzheimer Disease - genetics
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Animals
Antioxidants - metabolism
Antioxidants - pharmacology
Drug Delivery Systems
Humans
Mitochondria - drug effects
Mitochondria - metabolism
Mitochondrial Dynamics
Mitochondrial Proteins - metabolism
Models, Biological
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Parkinson Disease - drug therapy
Parkinson Disease - metabolism
Parkinson Disease - pathology
therapeutics
mitochondrial dysfunction
Parkinson's disease
Alzheimer's disease
ISSN:1470-8752, 1470-8752
Online-Zugang:Weitere Angaben
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Mitochondrial abnormalities have been identified as a central mechanism in multiple neurodegenerative diseases and, therefore, the mitochondria have been explored as a therapeutic target. This review will focus on the evidence for mitochondrial abnormalities in the two most common neurodegenerative diseases, Parkinson's disease and Alzheimer's disease. In addition, we discuss the main strategies which have been explored in these diseases to target the mitochondria for therapeutic purposes, focusing on mitochondrially targeted antioxidants, peptides, modulators of mitochondrial dynamics and phenotypic screening outcomes.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1470-8752
1470-8752
DOI:10.1042/BST20170501