Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

Mitochondrial abnormalities have been identified as a central mechanism in multiple neurodegenerative diseases and, therefore, the mitochondria have been explored as a therapeutic target. This review will focus on the evidence for mitochondrial abnormalities in the two most common neurodegenerative...

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Vydané v:	Biochemical Society transactions Ročník 46; číslo 4; s. 891
Hlavní autori:	Macdonald, Ruby, Barnes, Katy, Hastings, Christopher, Mortiboys, Heather
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 20.08.2018
Predmet:	Alzheimer Disease - drug therapy Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Animals Antioxidants - metabolism Antioxidants - pharmacology Drug Delivery Systems Humans Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Dynamics Mitochondrial Proteins - metabolism Models, Biological Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson Disease - pathology therapeutics mitochondrial dysfunction Parkinson's disease Alzheimer's disease
ISSN:	1470-8752, 1470-8752
On-line prístup:	Zistit podrobnosti o prístupe
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