Involvement of Galectin-1 Tumor Microenvironment in Radiosensitivity

The mechanisms of galectin-1 in radioresistance may not only involve intracellular but also extracellular effects because galectin-1 can be secreted into the extracellular matrix. We, therefore, aimed to investigate the role of the galectin-1 tumor microenvironment on radiosensitivity in a murine tu...

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Veröffentlicht in:Anticancer research Jg. 41; H. 5; S. 2321 - 2331
Hauptverfasser: CHEN, YI-FAN, WANG, CHUNG-CHI, HSU, CHIEH-YING, HUANG, ENG-YEN
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Greece International Institute of Anticancer Research 01.05.2021
Schlagworte:
Antibodies
Antigens
Cancer therapies
Cells
Extracellular matrix
Galectin-1
Immunohistochemistry
Irradiation
Laboratory animals
Lung cancer
Lymphocytes
Lymphocytes B
Lymphocytes T
Melanoma
Radiation
Radiation tolerance
Radioresistance
Radiosensitivity
Radiosensitization
Tumor microenvironment
Tumors
Viral infections
United States > US
Taiwan
Galectin-1
radiosensitivity
tumor microenvironment
ISSN:0250-7005, 1791-7530, 1791-7530
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Zusammenfassung:The mechanisms of galectin-1 in radioresistance may not only involve intracellular but also extracellular effects because galectin-1 can be secreted into the extracellular matrix. We, therefore, aimed to investigate the role of the galectin-1 tumor microenvironment on radiosensitivity in a murine tumor model. Wild-type or stable galectin-1-down-regulated cancer cells (melanoma (B16F10) and lung cancer (LLC1)) were injected (subcutaneous injection) into wild-type or knockout (galectin-1, B cells, and T cells) mice that were subject to 0 or 8 Gy irradiation. Galectin-1-down-regulated B16F10 cells showed increased radiosensitivity when injected into galectin-1 knockout mice. Interestingly, radioresistance of wild-type LCC1 tumors was noted when injected into galectin-1 and B cell knockout mice. However, radiosensitization was observed in T cell knockout mice with wild-type LCC1 cells. The role of endogenous galectin-1 in radioresistance exists in cases without extracellular galectin-1. Extracellular galectin-1 requires endogenous galectin-1 to radiosensitize tumors in mice.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0250-7005
1791-7530
1791-7530
DOI:10.21873/anticanres.15007