ONECUT2-driven activation of ADAMTS14 boosts colorectal cancer stemness via Wnt pathway

The malignant progression of colorectal cancer (CRC) is closely related to cell stemness, but its regulatory mechanism has not been fully elucidated. This study found that ADAMTS14 was significantly highly expressed in CRC tissues and cell lines and was associated with poor prognosis in patients. Fu...

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Veröffentlicht in:	Human cell : official journal of Human Cell Research Society Jg. 39; H. 1; S. 7
Hauptverfasser:	Jiang, Yicheng, Tan, Xingping
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Japan Springer Nature B.V 12.11.2025
Schlagworte:	ADAMTS Proteins - genetics ADAMTS Proteins - metabolism Bioinformatics Cell Line, Tumor Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Gene Expression Regulation, Neoplastic - genetics Humans Liver cancer Medical prognosis Metastasis Mortality Neoplastic Stem Cells - pathology Penicillin Plasmids Prognosis Signal transduction Stem cells Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Treatment resistance Wnt protein Wnt Signaling Pathway - genetics United States > US China Germany ADAMTS14 Cell stemness Wnt signaling pathway ONECUT2 Colorectal cancer
ISSN:	1749-0774, 0914-7470, 1749-0774
Online-Zugang:	Volltext
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