Breaking Boundaries in Histone Modification MS-Based Detection: A Tailored Search Strategy for Unrestricted Identification of Novel Epigenetic Marks

Histone post-translational modifications (PTMs) play a crucial role in regulating gene expression and maintaining DNA integrity, and their aberrations are linked to various diseases, including cancer. While lysine acetylation and methylation have been extensively studied, recent research has uncover...

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Bibliographic Details
Published in:	Molecular & cellular proteomics Vol. 24; no. 11; p. 101080
Main Authors:	Vai, Alessandro, Noberini, Roberta, Graziadei, Andrea, Polasky, Daniel A., Yu, Fengchao, Nesvizhskii, Alexey I., Bonaldi, Tiziana
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.11.2025
Subjects:	bioinformatics workflow epigenetics histone PTM discovery mass spectrometry post-translational modifications pr OS MS DMO PTM K PIC PSM PRO epigenetics bioinformatics workflow HiP-Frag R FDR LC mass spectrometry me3 post-translational modifications FA DIA histone PTM discovery AGE
ISSN:	1535-9476, 1535-9484, 1535-9484
Online Access:	Get full text
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