Post-Translational Modifications of the Werner Syndrome Protein WRN

Werner syndrome has been an excellent model for the study of human aging and how chromosomal instability is related to phenotypes of normal aging including cancer. George Martin devoted his life to the study of Werner syndrome and human aging, and this review is dedicated to his memory. In this revi...

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Vydáno v:Cytogenetic and genome research s. 1
Hlavní autoři: Machwe, Amrita, Orren, David K
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland 02.07.2025
Témata:
Premature aging disease
WRN acetylation
DNA metabolic disorder
WRN phosphorylation
Werner syndrome
ISSN:1424-859X, 1424-859X
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Shrnutí:Werner syndrome has been an excellent model for the study of human aging and how chromosomal instability is related to phenotypes of normal aging including cancer. George Martin devoted his life to the study of Werner syndrome and human aging, and this review is dedicated to his memory. In this review, we highlight the post-translational modifications of WRN, the protein whose function is lacking in individuals with Werner syndrome. WRN is subject to phosphorylation, acetylation, ubiquitination, and SUMOylation. These modifications of WRN control its localization and function in the response to replication fork stress and repair of double-strand breaks that are a consequence of this stress.
Bibliografie:ObjectType-Article-1
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ISSN:1424-859X
1424-859X
DOI:10.1159/000547163