Post-Translational Modifications of the Werner Syndrome Protein WRN

Werner syndrome has been an excellent model for the study of human aging and how chromosomal instability is related to phenotypes of normal aging including cancer. George Martin devoted his life to the study of Werner syndrome and human aging, and this review is dedicated to his memory. In this revi...

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Podrobná bibliografia
Vydané v:Cytogenetic and genome research s. 1
Hlavní autori: Machwe, Amrita, Orren, David K
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland 02.07.2025
Predmet:
Premature aging disease
WRN acetylation
DNA metabolic disorder
WRN phosphorylation
Werner syndrome
ISSN:1424-859X, 1424-859X
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Shrnutí:Werner syndrome has been an excellent model for the study of human aging and how chromosomal instability is related to phenotypes of normal aging including cancer. George Martin devoted his life to the study of Werner syndrome and human aging, and this review is dedicated to his memory. In this review, we highlight the post-translational modifications of WRN, the protein whose function is lacking in individuals with Werner syndrome. WRN is subject to phosphorylation, acetylation, ubiquitination, and SUMOylation. These modifications of WRN control its localization and function in the response to replication fork stress and repair of double-strand breaks that are a consequence of this stress.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1424-859X
1424-859X
DOI:10.1159/000547163