Clinical and Demographic Features Associated with the Isolation of Ceftriaxone-Resistant Enterobacteriaceae in a Private Hospital in Kingston, Jamaica

Data on the burden of extended-spectrum β-lactamase producing Enterobacterales are limited in Jamaica. This study aims to identify factors associated with the isolation of ceftriaxone-resistant Enterobacterales in patients at a private hospital in Jamaica through a retrospective case-control study c...

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Veröffentlicht in:The American journal of tropical medicine and hygiene Jg. 112; H. 5; S. 1123
Hauptverfasser: Mendoza, Matthew S, Coombs, Fredricka A, Fletcher, Hansel M, Liu, Eugene W
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.05.2025
Schlagworte:
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Case-Control Studies
Ceftriaxone - pharmacology
Ceftriaxone - therapeutic use
Cross Infection - drug therapy
Cross Infection - epidemiology
Cross Infection - microbiology
Drug Resistance, Bacterial
Enterobacteriaceae - drug effects
Enterobacteriaceae - isolation & purification
Enterobacteriaceae Infections - drug therapy
Enterobacteriaceae Infections - epidemiology
Enterobacteriaceae Infections - microbiology
Female
Hospitals, Private
Humans
Jamaica - epidemiology
Male
Microbial Sensitivity Tests
Middle Aged
Retrospective Studies
Jamaica
ISSN:1476-1645, 1476-1645
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Zusammenfassung:Data on the burden of extended-spectrum β-lactamase producing Enterobacterales are limited in Jamaica. This study aims to identify factors associated with the isolation of ceftriaxone-resistant Enterobacterales in patients at a private hospital in Jamaica through a retrospective case-control study comparing patients with and without ceftriaxone-resistant Enterobacterales in 2021. The case subjects had at least one Enterobacterales isolate resistant to ceftriaxone, and the controls had at least one culture, all without cephalosporin resistance, including those without growth. The data extracted included antibiotics received, organism, sex, and age. Older age, male sex, and the isolation of Enterobacter species were independently associated with increased odds of ceftriaxone-resistant Enterobacterales on logistic regression. Age and male sex may be markers for past exposure to β-lactam antibiotics or nosocomial infection with ceftriaxone-resistant Enterobacterales and may have a greater influence on isolation of ceftriaxone-resistant Enterobacterales compared with the receipt of antibiotics in the past six months, with which no association was observed on final analysis.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1476-1645
1476-1645
DOI:10.4269/ajtmh.24-0351