Expression pattern and prognostic significance of CDKs in breast cancer: An integrated bioinformatic study

Globally, breast cancer (BC) has become one of the most prevalent malignancies and the leading cause of tumor-related deaths among women. Dysregulation of the cell cycle is a well-known hallmark of cancer development and metastasis. CDKs are essential components of the cell-cycle regulatory system w...

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Bibliographic Details
Published in:Cancer biomarkers : section A of Disease markers Vol. 34; no. 3; p. 505
Main Authors: Mehraj, Umar, Sofi, Shazia, Alshehri, Bader, Mir, Manzoor A
Format: Journal Article
Language:English
Published: Netherlands 01.01.2022
Subjects:
Breast Neoplasms - pathology
Computational Biology - methods
Cyclin-Dependent Kinases - genetics
Cyclin-Dependent Kinases - metabolism
Cyclin-Dependent Kinases - therapeutic use
Female
Humans
Neoplasm Recurrence, Local
Prognosis
Breast cancer
prognostic factor
cell cycle
CDKs
gene expression
bioinformatics
ISSN:1875-8592, 1875-8592
Online Access:Get more information
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Summary:Globally, breast cancer (BC) has become one of the most prevalent malignancies and the leading cause of tumor-related deaths among women. Dysregulation of the cell cycle is a well-known hallmark of cancer development and metastasis. CDKs are essential components of the cell-cycle regulatory system with aberrant expression in a variety of cancers, including BC. In the development of targeted cancer treatment, reestablishing the regulation of the cell cycle by modulation of CDKs has emerged as a promising approach. Herein, we used a bioinformatic approach to assess the expression pattern, prognostic and diagnostic importance, and clinical relevance of CDKs in BC. Additionally, we conducted a functional enrichment analysis of deregulated CDKs using the STRING and KEGG databases to delineate the role of CDKs in breast tumorigenesis. Gene expression analysis revealed substantial deregulation of CDKs in BC, with CDK1, CDK11A, and CDK18 showing a fold change of >± 1.5. Also, metastatic tumors showed high expression of CDK1 in the single cell RNA sequencing analysis of primary and metastatic breast tumors. Additionally, it was found that dysregulated CDK expression affects overall survival (OS) and relapse-free survival (RFS) of BC patients. The study's multimodal analytical methodologies imply that modulating CDKs for BC treatment is a promising approach.
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ISSN:1875-8592
1875-8592
DOI:10.3233/CBM-210186