Treatment Outcomes for Malignant Peripheral Lung Tumours: A Prospective Single-Centre Comparison of Thermal Ablation, Surgery, and Radiotherapy

Background and Objectives: Lung cancer and pulmonary metastases are major causes of cancer-related mortality. Surgery is a standard curative approach, but many patients are ineligible due to age, comorbidities, or treatment preference. This study aimed to evaluate the safety, effectiveness, and qual...

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Vydané v:Medicina (Kaunas, Lithuania) Ročník 61; číslo 11; s. 1972
Hlavní autori: Mačionis, Aurimas, Maziliauskienė, Gertrūda, Dubeikaitė, Rūta, Balčiūnaitė, Ieva, Galnaitienė, Grytė, Padervinskienė, Lina, Matulionė, Jurgita, Miliauskas, Skaidrius, Korobeinikova, Erika, Jaruševičius, Laimonas, Nedzelskienė, Irena, Mišeikytė-Kaubrienė, Edita, Vajauskas, Donatas, Žemaitis, Marius
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 03.11.2025
Predmet:
Ablation
Ablation (Surgery)
Ablation Techniques - methods
Ablation Techniques - standards
Adult
Aged
Aged, 80 and over
Cancer therapies
Care and treatment
Comparative analysis
cryoablation
Dosimetry
Epidemiology
Female
Humans
image-guided thermal ablation
Lesions
Lithuania
Lung cancer
Lung diseases
lung metastases
Lung Neoplasms - radiotherapy
Lung Neoplasms - surgery
Male
Medical prognosis
Medical research
Medicine, Experimental
Metastasis
microwave ablation
Middle Aged
Mortality
Neoplasm Recurrence, Local
non-small cell lung cancer
Ostomy
Patient outcomes
Patients
Performance evaluation
Prospective Studies
Quality of Life
Radiation therapy
Radiosurgery - methods
Radiosurgery - standards
Radiotherapy
Surgery
Treatment Outcome
Tumors
United States
Lithuania
United States
Palo Alto California
United States > US
non-small cell lung cancer
treatment outcomes
cryoablation
microwave ablation
cancer recurrence
lung metastases
stereotactic body radiotherapy
image-guided thermal ablation
quality-of-life
surgery
ISSN:1648-9144, 1010-660X, 1648-9144
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Shrnutí:Background and Objectives: Lung cancer and pulmonary metastases are major causes of cancer-related mortality. Surgery is a standard curative approach, but many patients are ineligible due to age, comorbidities, or treatment preference. This study aimed to evaluate the safety, effectiveness, and quality-of-life outcomes of thermal ablation versus surgery and stereotactic body radiotherapy (SBRT) for malignant lung lesions. Materials and Methods: A prospective, non-randomized study was conducted on 68 patients with primary or metastatic lung tumours treated by surgery (n = 19), SBRT (n = 29), or thermal ablation (n = 20). The key outcomes included recurrence rates and patterns, disease-free and overall survival, complications, hospitalization, and health-related quality of life (HRQoL). Results: Surgery demonstrated the lowest total and regional recurrence rates (21.1% and 10.5%, respectively), significantly lower than SBRT (57.1% and 42.9%, respectively; p < 0.05). Additionally, surgery led to the longest disease-free survival but was associated with the highest complication rate (78.9%) and the greatest HRQoL decline. SBRT had fewer complications (17.2%) and moderate HRQoL outcomes. Thermal ablation showed no significant differences in recurrence (45.0% of total recurrence) or survival compared to surgery or SBRT, with a moderate complication rate (45.0%) and the most favorable HRQoL outcomes. Major complications were rare and comparable across all groups. Conclusions: Thermal ablation demonstrated comparable disease control and quality-of-life outcomes to SBRT, with lower complication rates. While surgery remains superior in local disease control, its invasiveness and impact on quality of life underscore the importance of minimally invasive treatments in multidisciplinary management of malignant lung lesions.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina61111972