Effects of citicoline on level of consciousness, serum level of fetuin-A and matrix Gla-protein (MGP) in trauma patients with diffuse axonal injury (DAI) and GCS≤8

Citicoline, a neuroprotective drug, has been suggested to improve level of consciousness, mitigating secondary to brain damage and ectopic vascular calcification, following post-traumatic neurogenesis and angiogenesis, inducing calcification modulators, like fetuin-A and matrix Gla-protein (MGP). Th...

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Veröffentlicht in:	Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES Jg. 20; H. 6; S. 410
Hauptverfasser:	Shokouhi, Ghaffar, Haghjoo, Amir Ghorbani, Sattarnezhad, Neda, Asghari, Mohammad, Sattarnezhad, Aida, Asghari, Ali, Pezeshki, Arastoo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Turkey 01.11.2014
Schlagworte:	Adolescent Adult Aged alpha-2-HS-Glycoprotein - metabolism Brain Injuries - blood Brain Injuries - complications Brain Injuries - drug therapy Calcium-Binding Proteins - blood Consciousness Cytidine Diphosphate Choline - administration & dosage Cytidine Diphosphate Choline - therapeutic use Diffuse Axonal Injury - complications Double-Blind Method Extracellular Matrix Proteins - blood Female Glasgow Coma Scale Humans Male Matrix Gla Protein Middle Aged Nootropic Agents - administration & dosage Nootropic Agents - therapeutic use Treatment Outcome Young Adult
ISSN:	1307-7945, 1307-7945
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Zusammenfassung:	Citicoline, a neuroprotective drug, has been suggested to improve level of consciousness, mitigating secondary to brain damage and ectopic vascular calcification, following post-traumatic neurogenesis and angiogenesis, inducing calcification modulators, like fetuin-A and matrix Gla-protein (MGP). This study aimed to investigate effects of citicoline on levels of consciousness, serum levels of fetuin-A and MGP in patients with severe traumatic brain injury. This double blind randomized controlled trial (RCT) was conducted on patients with diagnosis of diffuse axonal injury (DAI) and GCS≤8. The cases were treated with citicoline (500 mg every 6 hours) intravenously for fifteen days. Daily GCS assessment and intermittent blood sampling were done for both cases and controls. Fifty-eight patients were included in the study and during the study period, mean GCS levels improved in both groups; however, the difference was inconsiderable (p>0.05). Serum levels of fetuin-A, a negative phase reactant, increased in the group treated with citicoline (p=0.012), while these changes were insignificant for the controls (p=0.455). Serum levels of MGP, a calcification inhibitor, increased in the cases (p=0.046). The alterations were inconsequential in the control group (p=0.405). The findings of this study suggest neutral effects of citicoline on level of consciousness and GCS. Through increasing levels of fetuin-A and MGP, citicoline may have protective effects against inflammatory damage and vascular calcification secondary to head trauma.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	1307-7945 1307-7945
DOI:	10.5505/tjtes.2014.05769