Effects of citicoline on level of consciousness, serum level of fetuin-A and matrix Gla-protein (MGP) in trauma patients with diffuse axonal injury (DAI) and GCS≤8

Citicoline, a neuroprotective drug, has been suggested to improve level of consciousness, mitigating secondary to brain damage and ectopic vascular calcification, following post-traumatic neurogenesis and angiogenesis, inducing calcification modulators, like fetuin-A and matrix Gla-protein (MGP). Th...

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Vydané v:Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES Ročník 20; číslo 6; s. 410
Hlavní autori: Shokouhi, Ghaffar, Haghjoo, Amir Ghorbani, Sattarnezhad, Neda, Asghari, Mohammad, Sattarnezhad, Aida, Asghari, Ali, Pezeshki, Arastoo
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Turkey 01.11.2014
Predmet:
Adolescent
Adult
Aged
alpha-2-HS-Glycoprotein - metabolism
Brain Injuries - blood
Brain Injuries - complications
Brain Injuries - drug therapy
Calcium-Binding Proteins - blood
Consciousness
Cytidine Diphosphate Choline - administration & dosage
Cytidine Diphosphate Choline - therapeutic use
Diffuse Axonal Injury - complications
Double-Blind Method
Extracellular Matrix Proteins - blood
Female
Glasgow Coma Scale
Humans
Male
Matrix Gla Protein
Middle Aged
Nootropic Agents - administration & dosage
Nootropic Agents - therapeutic use
Treatment Outcome
Young Adult
ISSN:1307-7945, 1307-7945
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Shrnutí:Citicoline, a neuroprotective drug, has been suggested to improve level of consciousness, mitigating secondary to brain damage and ectopic vascular calcification, following post-traumatic neurogenesis and angiogenesis, inducing calcification modulators, like fetuin-A and matrix Gla-protein (MGP). This study aimed to investigate effects of citicoline on levels of consciousness, serum levels of fetuin-A and MGP in patients with severe traumatic brain injury. This double blind randomized controlled trial (RCT) was conducted on patients with diagnosis of diffuse axonal injury (DAI) and GCS≤8. The cases were treated with citicoline (500 mg every 6 hours) intravenously for fifteen days. Daily GCS assessment and intermittent blood sampling were done for both cases and controls. Fifty-eight patients were included in the study and during the study period, mean GCS levels improved in both groups; however, the difference was inconsiderable (p>0.05). Serum levels of fetuin-A, a negative phase reactant, increased in the group treated with citicoline (p=0.012), while these changes were insignificant for the controls (p=0.455). Serum levels of MGP, a calcification inhibitor, increased in the cases (p=0.046). The alterations were inconsequential in the control group (p=0.405). The findings of this study suggest neutral effects of citicoline on level of consciousness and GCS. Through increasing levels of fetuin-A and MGP, citicoline may have protective effects against inflammatory damage and vascular calcification secondary to head trauma.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1307-7945
1307-7945
DOI:10.5505/tjtes.2014.05769