Angiotensin-converting enzyme insertion/deletion gene polymorphism and interferon-β treatment response in multiple sclerosis patients: a preliminary report

We investigated the effect of the functional insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene on the response to interferon-β (IFN-β) therapy in Croatian and Slovenian patients with multiple sclerosis (MS). A total of 275 IFN-β treated MS patients [162 responders...

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Vydáno v:Pharmacogenetics and genomics Ročník 27; číslo 6; s. 232
Hlavní autoři: Ristić, Smiljana, Starčević Čizmarević, Nada, Lavtar, Polona, Lovrečić, Luca, Perković, Olivio, Sepčić, Juraj, Šega Jazbec, Saša, Kapović, Miljenko, Peterlin, Borut
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.06.2017
Témata:
Adult
Antineoplastic Agents - therapeutic use
Croatia
Female
Gene Frequency
Genotype
Humans
INDEL Mutation
Interferon-beta - therapeutic use
Male
Multiple Sclerosis - drug therapy
Multiple Sclerosis - genetics
Peptidyl-Dipeptidase A - genetics
Pharmacogenomic Variants
Slovenia
Treatment Outcome
Young Adult
ISSN:1744-6880, 1744-6880
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Popis
Shrnutí:We investigated the effect of the functional insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene on the response to interferon-β (IFN-β) therapy in Croatian and Slovenian patients with multiple sclerosis (MS). A total of 275 IFN-β treated MS patients [162 responders (Rs) and 113 nonresponders (NRs)] were genotyped by PCR. The ACE I/D genotype distribution and allele frequencies did not differ between female Rs and NRs. However, male NRs tended to have a greater prevalence of the DD genotype (P=0.073; odds ratio: 2.64; 95% confidence interval: 0.91-7.60) and a significantly higher frequency of the D allele (P=0.022; odds ratio: 2.43; 95% confidence interval: 1.13-5.20) than male Rs. Multiple forward stepwise regression analysis indicated that the negative response to IFN-β therapy was associated with the ACE-DD genotype in men (β=0.371; multiple R change: 0.132; P=0.009) and a higher pretreatment relapse rate in both men (β=-0.438; multiple R change: 0.135; P=0.015) and women (β=-0.208; multiple R change: 0.042; P=0.034). The ACE I/D polymorphism and pretreatment relapse rate accounted for ∼26.7% of the IFN-β response variability among the men in the sample. Further studies of a larger number of MS patients from different populations are necessary to evaluate these preliminary findings.
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ISSN:1744-6880
1744-6880
DOI:10.1097/FPC.0000000000000283