Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis: Results of Phase 1/2 and 2a Clinical Trials

Preclinical studies have shown that neurotrophic growth factors (NTFs) extend the survival of motor neurons in amyotrophic lateral sclerosis (ALS) and that the combined delivery of these neurotrophic factors has a strong synergistic effect. We have developed a culture-based method for inducing mesen...

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Vydané v:	JAMA neurology Ročník 73; číslo 3; s. 337
Hlavní autori:	Petrou, Panayiota, Gothelf, Yael, Argov, Zohar, Gotkine, Marc, Levy, Yossef S, Kassis, Ibrahim, Vaknin-Dembinsky, Adi, Ben-Hur, Tamir, Offen, Daniel, Abramsky, Oded, Melamed, Eldad, Karussis, Dimitrios
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.03.2016
Predmet:	Adult Aged Amyotrophic Lateral Sclerosis - therapy Female Follow-Up Studies Humans Male Mesenchymal Stem Cell Transplantation - adverse effects Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stromal Cells - secretion Middle Aged Nerve Growth Factors - secretion Outcome Assessment (Health Care) Transplantation, Autologous Young Adult
ISSN:	2168-6157, 2168-6157
On-line prístup:	Zistit podrobnosti o prístupe
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