Synthesis and Antiarrhythmic and Anticonvulsant Activities of Amino Amides and Amino Esters Based on 1-(4-Fluorophenyl)- and 1-[3-(Trifluoromethyl)phenyl]cyclopentane-1-carboxylic Acids

The alkylation of 2-(4-fluorophenyl)- and 2-[3-(trifluoromethyl)phenyl]acetonitriles with 1,4-dibromobutane gave 1-(substituted phenyl)cyclopentane-1-carbonitriles which were hydrolyzed to the corresponding carboxylic acids by the action of potassium hydroxide in ethylene glycol. The resulting ac...

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Bibliographic Details
Published in:	Russian journal of organic chemistry Vol. 60; no. 6; pp. 1028 - 1035
Main Authors:	Arustamyan, J. S., Margaryan, R. E., Aghekyan, A. A., Mkrtchyan, G. S., Muradyan, R. E., Grigoryan, M. S., Panosyan, H. A., Mkryan, G. G.
Format:	Journal Article
Language:	English
Published:	Moscow Pleiades Publishing 01.06.2024 PLEIADES PUBLISHING LTD Springer Nature B.V
Subjects:	Acids Alkylation Amides Antiarrhythmics Anticonvulsants Carboxylic acids Caustic soda Chemistry Chemistry and Materials Science Chemistry, Organic Chloride Cooling Drug dosages Esters Ethylene glycol Fluorine Hydrocarbons Hydrochloric acid Hydrochlorides Mineral oils Organic Chemistry Physical Sciences Potash Potassium Potassium hydroxides Science & Technology Sodium Solvents United States > US dialkylaminoalkylamines 1-[3-(trifluoromethyl)phenyl]cyclopentane-1-carboxylic acid dialkylaminoalkanols 1-(4-fluorophenyl)cyclopentane-1-carboxylic acid amino esters amino amides FLUORINE
ISSN:	1070-4280, 1608-3393
Online Access:	Get full text
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