Novel mutation of the cyclin-dependent kinase 4 gene in a Chinese patient with intimal sarcoma of the pulmonary artery
The long arm of human chromosome 12 contains a region that has been found to be amplified in a number of different tumors, including osteosarcomas and soft tissue sarcomas. There are more than 5 genes located in this area such as CDK2, CDK4, WNT1, MDM2 and WNTIOb. CDK4 gene consists of eight exons,...
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| Abstract | The long arm of human chromosome 12 contains a region that has been found to be amplified in a number of different tumors, including osteosarcomas and soft tissue sarcomas. There are more than 5 genes located in this area such as CDK2, CDK4, WNT1, MDM2 and WNTIOb. CDK4 gene consists of eight exons, of which the start codon is located in the beginning of exon 2 and the stop codon in the a member of the Ser-Thr catalytic domain extends beginning of exon 8. CDK4 is protein kinase family and its from amino acid 6 to 295. |
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| AbstractList | The long arm of human chromosome 12 contains a region that has been found to be amplified in a number of different tumors, including osteosarcomas and soft tissue sarcomas. There are more than 5 genes located in this area such as CDK2, CDK4, WNT1, MDM2 and WNTIOb. CDK4 gene consists of eight exons, of which the start codon is located in the beginning of exon 2 and the stop codon in the a member of the Ser-Thr catalytic domain extends beginning of exon 8. CDK4 is protein kinase family and its from amino acid 6 to 295. |
| Author | GAO Feng LIU Qi-cai WANG Mi WANG Zhi-qiang HUANG Yi ZHOU Xiao-hui ZHANG Sheng |
| AuthorAffiliation | Department of Pathology,First Affiliated Hospital,Fujian Medical University, Fuzhou, Fujian350005, China Department of Laboratory Medicine,First Affiliated Hospital,Fujian Medical University, Fuzhou, Fujian350005, China Department of Gene Diagnosis,First Affiliated Hospital,Fujian Medical University, Fuzhou, Fujian350005, China Department of Neurology,First Affiliated Hospital,Fujian Medical University, Fuzhou, Fujian350005, China Department of Chemistry,First Affiliated Hospital,Fujian Medical University, Fuzhou, Fujian350005, China |
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| Keywords | CDK4 gene pulmonary artery clinical character intimal sarcoma |
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| SubjectTerms | 12号染色体 CDK4基因 Cyclin-Dependent Kinase 4 - genetics Exons - genetics Humans Magnetic Resonance Imaging Mutation - genetics Polymerase Chain Reaction Polymorphism, Genetic - genetics Pulmonary Artery - metabolism Pulmonary Artery - pathology Sarcoma - genetics 第8外显子 细胞周期蛋白依赖性激酶4 肺动脉 软组织肉瘤 |
| Title | Novel mutation of the cyclin-dependent kinase 4 gene in a Chinese patient with intimal sarcoma of the pulmonary artery |
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