Leber's hereditary optic neuropathy-associated ND6 14484T > C mutation caused pleiotropic effects on the complex I, RNA homeostasis, apoptosis and mitophagy

Leber's hereditary optic neuropathy (LHON) is a maternally inherited eye disease due to mitochondrial DNA (mtDNA) mutations. LHON-linked ND6 14484T > C (p.M64V) mutation affected structural components of complex I but its pathophysiology is poorly understood. The structural analysis of compl...

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Bibliographic Details

Published in:	Human molecular genetics Vol. 31; no. 19; p. 3299
Main Authors:	Liang, Min, Ji, Yanchun, Zhang, Liyao, Wang, Xuan, Hu, Cuifang, Zhang, Juanjuan, Zhu, Yiwei, Mo, Jun Q, Guan, Min-Xin
Format:	Journal Article
Language:	English
Published:	29.09.2022
ISSN:	1460-2083, 1460-2083
Online Access:	Get more information
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