Transcriptional state and function of CD8 + memory T cells is linked to past proliferation

A new genetic ‘recorder’ of long-term cell proliferation revealed substantial heterogeneity in the division history of central memory CD8+ T cells. Importantly, the extent of past proliferation was related to distinct transcriptional features and re-expansion potential, highlighting an unappreciated...

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Veröffentlicht in:Nature immunology Jg. 23; H. 5; S. 658 - 659
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Nature Publishing Group 01.05.2022
Schlagworte:
CD8 antigen
Cell cycle
Cell growth
Cell proliferation
Division of labor
Genetic engineering
Heterogeneity
Immunological memory
Immunology
Infections
Lymphocytes
Lymphocytes T
Memory cells
Population
Stem cells
ISSN:1529-2908, 1529-2916, 1529-2916
Online-Zugang:Volltext
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Zusammenfassung:A new genetic ‘recorder’ of long-term cell proliferation revealed substantial heterogeneity in the division history of central memory CD8+ T cells. Importantly, the extent of past proliferation was related to distinct transcriptional features and re-expansion potential, highlighting an unappreciated division of labor within the central memory T cell pool.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1529-2908
1529-2916
1529-2916
DOI:10.1038/s41590-022-01169-3