Transcriptional state and function of CD8 + memory T cells is linked to past proliferation

A new genetic ‘recorder’ of long-term cell proliferation revealed substantial heterogeneity in the division history of central memory CD8+ T cells. Importantly, the extent of past proliferation was related to distinct transcriptional features and re-expansion potential, highlighting an unappreciated...

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Veröffentlicht in:Nature immunology Jg. 23; H. 5; S. 658 - 659
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Nature Publishing Group 01.05.2022
Schlagworte:
CD8 antigen
Cell cycle
Cell growth
Cell proliferation
Division of labor
Genetic engineering
Heterogeneity
Immunological memory
Immunology
Infections
Lymphocytes
Lymphocytes T
Memory cells
Population
Stem cells
ISSN:1529-2908, 1529-2916, 1529-2916
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Abstract A new genetic ‘recorder’ of long-term cell proliferation revealed substantial heterogeneity in the division history of central memory CD8+ T cells. Importantly, the extent of past proliferation was related to distinct transcriptional features and re-expansion potential, highlighting an unappreciated division of labor within the central memory T cell pool.
AbstractList A new genetic ‘recorder’ of long-term cell proliferation revealed substantial heterogeneity in the division history of central memory CD8+ T cells. Importantly, the extent of past proliferation was related to distinct transcriptional features and re-expansion potential, highlighting an unappreciated division of labor within the central memory T cell pool.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35393593$$D View this record in MEDLINE/PubMed
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Snippet A new genetic ‘recorder’ of long-term cell proliferation revealed substantial heterogeneity in the division history of central memory CD8+ T cells....
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SubjectTerms CD8 antigen
Cell cycle
Cell growth
Cell proliferation
Division of labor
Genetic engineering
Heterogeneity
Immunological memory
Immunology
Infections
Lymphocytes
Lymphocytes T
Memory cells
Population
Stem cells
Title Transcriptional state and function of CD8 + memory T cells is linked to past proliferation
URI https://www.ncbi.nlm.nih.gov/pubmed/35393593
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