The effects of low-dose ketamine and (2R,6R)-Hydroxynorketamine on affective behaviors associated with protracted oxycodone withdrawal

In subjects with opioid use disorder (OUD), affective symptoms persist long after opioid cessation and contribute to poor treatment outcomes. (2R,6R)-Hydroxynorketamine (HNK), a ketamine metabolite, has emerged as promising rapid-acting and long-lasting antidepressants, but its potential to reduce a...

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Bibliographic Details
Published in:	Psychopharmacology
Main Authors:	Lehane, Michael J., Sartor, Gregory C.
Format:	Journal Article
Language:	English
Published:	Germany 04.10.2025
Subjects:	AMPA receptor Affective symptoms Ketamine Oxycodone Protracted withdrawal Opioid use disorder (2R,6R)-Hydroxynorketamine
ISSN:	0033-3158, 1432-2072, 1432-2072
Online Access:	Get full text
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