Signaling pathways associated with interleukins 12 and 23 and epigenetic mechanism of sequential-specific regulation of expression of related genes by miRNAs as molecular markers for assessing the potential of anti-cytokine therapies

The molecular targeted therapy is focused on blocking the activity of specific cytokines and the signalling cascades they activate. In the treatment of psoriasis, this type of therapy is based on treatment with anti-tumor necrosis factor drugs, anti-IL-12/23, anti-IL-17, inhibitors of JAK kinases. I...

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Veröffentlicht in:	Przegląd dermatologiczny Jg. 106; H. 1; S. 71 - 80
Hauptverfasser:	Grabarek, Beniamin O., Wcisło-Dziadecka, Dominika L., Mazurek, Urszula
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Poznan Termedia Publishing House 01.01.2019
Schlagworte:	anti-cytokine therapies Cytokines DNA methylation epigenetic Epigenetics Gene expression inflammatory process molecular marker signaling pathways TNF inhibitors
ISSN:	0033-2526, 2084-9893
Online-Zugang:	Volltext
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