Cigarette smoke-induced alveolar epithelial–mesenchymal transition is mediated by Rac1 activation

Epithelial-mesenchymal transition (EMT) is the major pathophysiological process in lung fibrosis observed in chronic obstructive pulmonary disease (COPD) and lung cancer. Smoking is a risk factor for developing EMT, yet the mechanism remains largely unknown. In this study, we investigated the role o...

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Vydané v:	Biochimica et biophysica acta Ročník 1840; číslo 6; s. 1838 - 1849
Hlavní autori:	Shen, Hui-juan, Sun, Yan-hong, Zhang, Shui-juan, Jiang, Jun-xia, Dong, Xin-wei, Jia, Yong-liang, Shen, Jian, Guan, Yan, Zhang, Lin-hui, Li, Fen-fen, Lin, Xi-xi, Wu, Xi-mei, Xie, Qiang-min, Yan, Xiao-feng
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands 01.06.2014
Predmet:	Animals cigarettes epithelial cells Epithelial-Mesenchymal Transition epithelium fibrosis lung neoplasms Mice Mice, Inbred C57BL Neuropeptides - physiology Nicotiana - adverse effects non-specific serine/threonine protein kinase phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - physiology Proto-Oncogene Proteins c-akt - physiology Pulmonary Alveoli - pathology rac1 GTP-Binding Protein - physiology risk factors signal transduction Smad2 Protein - physiology Smoke - adverse effects therapeutics transforming growth factor beta 1 Transforming Growth Factor beta1 - analysis Transforming Growth Factor beta1 - biosynthesis Epithelial–mesenchymal transition TGF-β1 Pulmonary fibrosis Rac1 Cigarette smoke extract
ISSN:	0304-4165, 0006-3002
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