A biotin-selective molecular imprinted polymer containing Fe3O4 nanoparticles and CD44-selective aptamer for targeting cancer hyperthermia therapy
An effective combination of magnetic nanoparticles and biotin-selective molecular imprinted polymer (MIP) with CD44 recognition of aptamer under magnetic hyperthermia conditions is a novel platform for cancer therapy. Herein, we construct a magnetically directed MIP with selectivity for biotin that...
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| Published in: | Journal of drug delivery science and technology Vol. 109; p. 106972 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
01.07.2025
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| ISSN: | 1773-2247 |
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| Abstract | An effective combination of magnetic nanoparticles and biotin-selective molecular imprinted polymer (MIP) with CD44 recognition of aptamer under magnetic hyperthermia conditions is a novel platform for cancer therapy. Herein, we construct a magnetically directed MIP with selectivity for biotin that functions as an adaptor to connect any materials recognized by the biotin molecule, thereby enabling an intelligent drug delivery system. To prove the concept, we synthesize MIP-containing magnetic Fe3O4 nanoparticles that can be guided by magnetic fields (MF) and induce heat under an alternating magnetic field (AMF) for hypothermia therapy. A biotin-labeled CD44-selective aptamer is selected as a cancer cell-recognizing motif for cancer cells with overexpressed CD44. This CD44-targeting MIP elevates temperature to 45–50 °C within 10 min and kills HT1080 cells under MF and AM F. The cell-killing mechanism is proven to be major by necroptosis and minor by ferroptosis under AMF. In advance, this intriguing biotin-selective MIP can rapidly replace other biotinylated cancer-targeting motifs recognized as the same as CD44 upon cancer cell mutations for cancer-targeted hyperthermia therapy.
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| AbstractList | An effective combination of magnetic nanoparticles and biotin-selective molecular imprinted polymer (MIP) with CD44 recognition of aptamer under magnetic hyperthermia conditions is a novel platform for cancer therapy. Herein, we construct a magnetically directed MIP with selectivity for biotin that functions as an adaptor to connect any materials recognized by the biotin molecule, thereby enabling an intelligent drug delivery system. To prove the concept, we synthesize MIP-containing magnetic Fe3O4 nanoparticles that can be guided by magnetic fields (MF) and induce heat under an alternating magnetic field (AMF) for hypothermia therapy. A biotin-labeled CD44-selective aptamer is selected as a cancer cell-recognizing motif for cancer cells with overexpressed CD44. This CD44-targeting MIP elevates temperature to 45–50 °C within 10 min and kills HT1080 cells under MF and AM F. The cell-killing mechanism is proven to be major by necroptosis and minor by ferroptosis under AMF. In advance, this intriguing biotin-selective MIP can rapidly replace other biotinylated cancer-targeting motifs recognized as the same as CD44 upon cancer cell mutations for cancer-targeted hyperthermia therapy.
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| ArticleNumber | 106972 |
| Author | Lo, Yu-Lun Ravula, Venkatesh Li, Chien-Hung Hung, Chia-Hsing Yang, Feng-Shuo Wang, Li-Fang |
| Author_xml | – sequence: 1 givenname: Feng-Shuo orcidid: 0000-0001-7256-2465 surname: Yang fullname: Yang, Feng-Shuo organization: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, 80708, Taiwan – sequence: 2 givenname: Chia-Hsing surname: Hung fullname: Hung, Chia-Hsing organization: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, 80708, Taiwan – sequence: 3 givenname: Yu-Lun surname: Lo fullname: Lo, Yu-Lun organization: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, 80708, Taiwan – sequence: 4 givenname: Chien-Hung surname: Li fullname: Li, Chien-Hung organization: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, 80708, Taiwan – sequence: 5 givenname: Venkatesh orcidid: 0000-0002-0229-7640 surname: Ravula fullname: Ravula, Venkatesh organization: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, 80708, Taiwan – sequence: 6 givenname: Li-Fang surname: Wang fullname: Wang, Li-Fang email: lfwang@kmu.edu.tw organization: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, 80708, Taiwan |
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| Keywords | Magnetic guidance Molecularly imprinted polymer Fe3O4 nanoparticles CD44 aptamer Hyperthermia therapy |
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