A biotin-selective molecular imprinted polymer containing Fe3O4 nanoparticles and CD44-selective aptamer for targeting cancer hyperthermia therapy

An effective combination of magnetic nanoparticles and biotin-selective molecular imprinted polymer (MIP) with CD44 recognition of aptamer under magnetic hyperthermia conditions is a novel platform for cancer therapy. Herein, we construct a magnetically directed MIP with selectivity for biotin that...

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Vydáno v:Journal of drug delivery science and technology Ročník 109; s. 106972
Hlavní autoři: Yang, Feng-Shuo, Hung, Chia-Hsing, Lo, Yu-Lun, Li, Chien-Hung, Ravula, Venkatesh, Wang, Li-Fang
Médium: Journal Article
Jazyk:angličtina
Vydáno: Elsevier B.V 01.07.2025
Témata:
CD44 aptamer
Fe3O4 nanoparticles
Hyperthermia therapy
Magnetic guidance
Molecularly imprinted polymer
Magnetic guidance
Molecularly imprinted polymer
Fe3O4 nanoparticles
CD44 aptamer
Hyperthermia therapy
ISSN:1773-2247
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Shrnutí:An effective combination of magnetic nanoparticles and biotin-selective molecular imprinted polymer (MIP) with CD44 recognition of aptamer under magnetic hyperthermia conditions is a novel platform for cancer therapy. Herein, we construct a magnetically directed MIP with selectivity for biotin that functions as an adaptor to connect any materials recognized by the biotin molecule, thereby enabling an intelligent drug delivery system. To prove the concept, we synthesize MIP-containing magnetic Fe3O4 nanoparticles that can be guided by magnetic fields (MF) and induce heat under an alternating magnetic field (AMF) for hypothermia therapy. A biotin-labeled CD44-selective aptamer is selected as a cancer cell-recognizing motif for cancer cells with overexpressed CD44. This CD44-targeting MIP elevates temperature to 45–50 °C within 10 min and kills HT1080 cells under MF and AM F. The cell-killing mechanism is proven to be major by necroptosis and minor by ferroptosis under AMF. In advance, this intriguing biotin-selective MIP can rapidly replace other biotinylated cancer-targeting motifs recognized as the same as CD44 upon cancer cell mutations for cancer-targeted hyperthermia therapy. [Display omitted]
ISSN:1773-2247
DOI:10.1016/j.jddst.2025.106972