Robust variability of grid cell properties within individual grid modules enhances encoding of local space

Although grid cells are one of the most well-studied functional classes of neurons in the mammalian brain, whether there is a single orientation and spacing value per grid module has not been carefully tested. We analyze a recent large-scale recording of medial entorhinal cortex to characterize the...

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Vydáno v:eLife Ročník 13
Hlavní autoři: Redman, William T, Acosta-Mendoza, Santiago, Wei, Xue-Xin, Goard, Michael J
Médium: Journal Article
Jazyk:angličtina
Vydáno: England eLife Sciences Publications, Ltd 20.02.2025
eLife Sciences Publications Ltd
Témata:
Action Potentials
Animals
entorhinal cortex
Entorhinal Cortex - cytology
Entorhinal Cortex - physiology
grid cells
Grid Cells - physiology
Models, Neurological
Neuroscience
Space Perception - physiology
spatial coding
mouse
entorhinal cortex
grid cells
spatial coding
neuroscience
ISSN:2050-084X, 2050-084X
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Popis
Shrnutí:Although grid cells are one of the most well-studied functional classes of neurons in the mammalian brain, whether there is a single orientation and spacing value per grid module has not been carefully tested. We analyze a recent large-scale recording of medial entorhinal cortex to characterize the presence and degree of heterogeneity of grid properties within individual modules. We find evidence for small, but robust, variability and hypothesize that this property of the grid code could enhance the encoding of local spatial information. Performing analysis on synthetic populations of grid cells, where we have complete control over the amount heterogeneity in grid properties, we demonstrate that grid property variability of a similar magnitude to the analyzed data leads to significantly decreased decoding error. This holds even when restricted to activity from a single module. Our results highlight how the heterogeneity of the neural response properties may benefit coding and opens new directions for theoretical and experimental analysis of grid cells.
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These authors contributed equally to this work.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.100652