Quelle valeur clinique accorder aux résultats chiffrés des dosages d'IgE spécifiques ?
Les explorations in vitro en allergie ont recours principalement aux dosages des IgE « spécifiques » (IgE-S). Ces tests sont souvent dénommés RASTs et leurs résultats exprimés à la fois en unités semi-quantitatives, les classes et en valeurs chiffrées, les kU l –1. Ce double système a-t-il obscurci...
Saved in:
| Published in: | Immuno-analyse & biologie spécialisée Vol. 18; no. 3; pp. 144 - 151 |
|---|---|
| Main Author: | |
| Format: | Journal Article |
| Language: | French |
| Published: |
Paris
Elsevier SAS
2003
Elsevier |
| Subjects: | |
| ISSN: | 0923-2532, 1878-1365 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Les explorations in vitro en allergie ont recours principalement aux dosages des IgE « spécifiques » (IgE-S). Ces tests sont souvent dénommés RASTs et leurs résultats exprimés à la fois en unités semi-quantitatives, les classes et en valeurs chiffrées, les kU l
–1. Ce double système a-t-il obscurci la valeur et donc l’utilité clinique des résultats chiffrés des tests in vitro ? Les dosages sanguins sont-ils en soi suffisants pour poser un diagnostic d’allergie ou pour prédire une future allergie ? Les courbes de risque récemment proposées et fondées sur des études de populations peuvent-elles améliorer l’efficacité des tests in vitro de ce point de vue ? Cet article analyse ces questions sur la base d’arguments théoriques et expérimentaux. Il en ressort que les résultats chiffrés des dosages d'IgE-S ne traduisent pas fidèlement l'expression clinique du patient et ne doivent donc être interprétés qu'avec le reste du dossier du patient. Les courbes de risque ne sont pas une meilleure solution car elles ajoutent à ces limitations des IgE-S un autre problème : ces courbes sont fortement dépendantes des caractéristiques des cohortes de sujets qui ont servi à les calculer (âge, environnement etc.). Aussi, l'intérêt de ces courbes pour un patient donné est très limité en pratique quotidienne.
In vitro allergy testing is mainly based on the measurement of so-called specific IgEs in serum. These assays are commonly referred to as RASTs. Their results are expressed both in semi-quantitative and quantitative units, i.e. classes and kU l
–1, respectively. Has this double system been detrimental to correctly appraise and use quantitative RAST results? Are the serum blood tests self-sufficient to establish a diagnosis of allergy or to predict the development of a future allergy? And, in this respect, can population–based risk curves, as those recently suggested, improve the efficiency of in vitro allergy testing? This article discusses these different aspects on theoretical arguments as well as on reviewing experimental data. It is concluded that quantitative RAST results must not be interpreted indepedently of clinical information because they do not properly parallel patient reactions. Risk curves add another drawback to quantitative RAST result shortcomings: they largely depend on the subjects recruited to calculate them (eg. age or allergenic environment). So these curves are of limited value for a given patient in daily practice. |
|---|---|
| AbstractList | Les explorations in vitro en allergie ont recours principalement aux dosages des IgE « spécifiques » (IgE-S). Ces tests sont souvent dénommés RASTs et leurs résultats exprimés à la fois en unités semi-quantitatives, les classes et en valeurs chiffrées, les kU l
–1. Ce double système a-t-il obscurci la valeur et donc l’utilité clinique des résultats chiffrés des tests in vitro ? Les dosages sanguins sont-ils en soi suffisants pour poser un diagnostic d’allergie ou pour prédire une future allergie ? Les courbes de risque récemment proposées et fondées sur des études de populations peuvent-elles améliorer l’efficacité des tests in vitro de ce point de vue ? Cet article analyse ces questions sur la base d’arguments théoriques et expérimentaux. Il en ressort que les résultats chiffrés des dosages d'IgE-S ne traduisent pas fidèlement l'expression clinique du patient et ne doivent donc être interprétés qu'avec le reste du dossier du patient. Les courbes de risque ne sont pas une meilleure solution car elles ajoutent à ces limitations des IgE-S un autre problème : ces courbes sont fortement dépendantes des caractéristiques des cohortes de sujets qui ont servi à les calculer (âge, environnement etc.). Aussi, l'intérêt de ces courbes pour un patient donné est très limité en pratique quotidienne.
In vitro allergy testing is mainly based on the measurement of so-called specific IgEs in serum. These assays are commonly referred to as RASTs. Their results are expressed both in semi-quantitative and quantitative units, i.e. classes and kU l
–1, respectively. Has this double system been detrimental to correctly appraise and use quantitative RAST results? Are the serum blood tests self-sufficient to establish a diagnosis of allergy or to predict the development of a future allergy? And, in this respect, can population–based risk curves, as those recently suggested, improve the efficiency of in vitro allergy testing? This article discusses these different aspects on theoretical arguments as well as on reviewing experimental data. It is concluded that quantitative RAST results must not be interpreted indepedently of clinical information because they do not properly parallel patient reactions. Risk curves add another drawback to quantitative RAST result shortcomings: they largely depend on the subjects recruited to calculate them (eg. age or allergenic environment). So these curves are of limited value for a given patient in daily practice. |
| Author | Malandain, H |
| Author_xml | – sequence: 1 givenname: H surname: Malandain fullname: Malandain, H email: henri.malandain@ch-bretagne-atlantique.fr organization: Laboratoire de biochimie, centre hospitalier Chubert, 56000 Vannes, France |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14798684$$DView record in Pascal Francis |
| BookMark | eNqFkM1KxDAQx4MouH48gpCLqIfqpOm2KR5ExC8QRNSDpzA7nWiktmvSLvpIPocv5tYVD148DMPA_zfD_NbEctM2LMSWgn0FKj-4hTLVSTrW6S7oPQDIiiRbEiNlCpMonY-Xxeg3sirWYnwGSBVkMBIPNz3XNcsZ1twHSbVv_GvPEonaUHGQ2L_J8PkR-7rDLkp68s4Ns6x4Xm3Ex6HvXD6eyjj9_CDvBj7Kow2x4rCOvPnT18X92endyUVydX1-eXJ8lVA6TruEU5OWmJsK0ZA2BFkGJSqCkou8ypDNRE_I6GJCSjt0oFnzxLDLHemCQa-L7cXeKUbC2gVsyEc7Df4Fw7tVWVGa3GTz3OEiR6GNMbCz5Ocv-bbpAvraKrCDTftt0w6qLGj7bdMO9PgP_XvgH-5owfFcwcxzsJE8N8SVD0ydrVr_z4YvrByRaw |
| CitedBy_id | crossref_primary_10_1016_j_immbio_2005_11_003 crossref_primary_10_1157_13084224 crossref_primary_10_1111_j_1398_9995_2006_01078_x |
| Cites_doi | 10.1046/j.0022-0477.2001.01289.x 10.1067/mai.2000.107041 10.1067/mai.2001.111592 10.1067/mai.2002.121946 10.1046/j.0022-202x.2001.01470.x 10.1016/S0091-6749(99)70480-X 10.1111/j.1398-9995.1997.tb01251.x 10.1034/j.1399-3038.1999.101012.x 10.1111/j.1365-2222.1997.tb01252.x 10.1016/S0091-6749(02)81445-2 10.1067/mai.2001.112849 10.1111/j.1365-2222.1994.tb00250.x 10.2500/108854194778816508 10.1016/S0091-6749(97)70133-7 10.1016/S1081-1206(10)62415-5 10.1001/archotol.124.12.1337 10.1067/mai.2002.124775 10.1111/j.1398-9995.1996.tb00150.x 10.1016/0091-6749(93)90169-G 10.1046/j.1365-2222.2001.01113.x 10.1016/S0091-6749(99)70478-1 10.1034/j.1398-9995.2002.1o3319.x 10.1046/j.1365-2222.2000.00924.x 10.1067/mai.2000.108711 10.1067/mai.2001.120013 10.1046/j.1365-2222.2001.01175.x 10.1128/CDLI.8.6.1145-1149.2001 10.1016/S0091-6749(96)70278-6 10.1111/j.1398-9995.1998.tb04940.x 10.1016/S0091-6749(99)70095-3 10.1046/j.0022-0477.2001.01265.x 10.1034/j.1398-9995.2002.1o3413.x 10.1016/S0091-6749(97)70265-3 10.1067/mai.2001.114708 10.1046/j.1365-2222.2002.01396.x 10.1016/S0091-6749(99)70195-8 10.1016/0091-6749(94)90184-8 10.1096/fj.01-0711fje 10.1016/S0091-6749(99)70171-5 10.1111/j.1398-9995.1998.tb03972.x 10.1034/j.1398-9995.2000.00383.x 10.1016/S0022-3476(96)70337-2 10.1016/S0194-5998(00)70146-X |
| ContentType | Journal Article |
| Copyright | 2003 Éditions scientifiques et médicales Elsevier SAS 2003 INIST-CNRS |
| Copyright_xml | – notice: 2003 Éditions scientifiques et médicales Elsevier SAS – notice: 2003 INIST-CNRS |
| DBID | AAYXX CITATION IQODW |
| DOI | 10.1016/S0923-2532(03)00047-4 |
| DatabaseName | CrossRef Pascal-Francis |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| DocumentTitleAlternate | Are quantitative results of serum specific IgE assays clinically meaningful? |
| EISSN | 1878-1365 |
| EndPage | 151 |
| ExternalDocumentID | 14798684 10_1016_S0923_2532_03_00047_4 S0923253203000474 |
| GroupedDBID | --K --M .~1 0R~ 1B1 1RT 1~. 1~5 29I 4.4 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM AAAJQ AACTN AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AAXUO ABBQC ABGSF ABLVK ABMAC ABUDA ABXDB ABYKQ ACDAQ ACGFS ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEKER AFKWA AFTJW AFXIZ AGEKW AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q HDU HMK HMO HVGLF HZ~ IHE J1W KOM LCYCR LN9 LUGTX M27 M41 MO0 N9A O9- OAUVE OZT P-8 P-9 PC. Q38 R2- RIG ROL RPZ SAE SDF SDG SEM SES SEW SSH SSI SSU SSZ T5K UHS WUQ ~S- 9DU AATTM AAXKI AAYWO AAYXX ABJNI ABWVN ACIEU ACLOT ACRPL ADNMO AEIPS AGQPQ AIIUN ANKPU CITATION EFKBS ~HD AGCQF AGRNS IQODW |
| ID | FETCH-LOGICAL-c252t-e2829a68daa8c38c04409a1c09e76d4ae8b3bc837bc13faf03e3eb8ef6fc37e03 |
| ISSN | 0923-2532 |
| IngestDate | Mon Jul 21 09:15:21 EDT 2025 Tue Nov 18 22:18:07 EST 2025 Sat Nov 29 06:29:04 EST 2025 Fri Feb 23 02:30:51 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | Result interpretation Allergy Courbes de risque Specific IgE Allergie IgE spécifiques Diagnostic Diagnosis Risk curves Interprétation des résultats Immunopathologie Homme Interprétation Analyse quantitative IgE spécifique Pronostic Facteur risque |
| Language | French |
| License | https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c252t-e2829a68daa8c38c04409a1c09e76d4ae8b3bc837bc13faf03e3eb8ef6fc37e03 |
| PageCount | 8 |
| ParticipantIDs | pascalfrancis_primary_14798684 crossref_citationtrail_10_1016_S0923_2532_03_00047_4 crossref_primary_10_1016_S0923_2532_03_00047_4 elsevier_sciencedirect_doi_10_1016_S0923_2532_03_00047_4 |
| PublicationCentury | 2000 |
| PublicationDate | 2003-00-00 |
| PublicationDateYYYYMMDD | 2003-01-01 |
| PublicationDate_xml | – year: 2003 text: 2003-00-00 |
| PublicationDecade | 2000 |
| PublicationPlace | Paris |
| PublicationPlace_xml | – name: Paris |
| PublicationTitle | Immuno-analyse & biologie spécialisée |
| PublicationYear | 2003 |
| Publisher | Elsevier SAS Elsevier |
| Publisher_xml | – name: Elsevier SAS – name: Elsevier |
| References | Pastorello, Pravettoni, Farioli, Ispano, Fortunato, Monza (BIB6) 1999; 104 Garcia-Ara, Boyano-Martinez, Diaz-Pena, Martin-Munoz, Reche-Frutos, Martin-Esteban (BIB32) 2001; 107 Biagini, Krieg, Pinkerton, Hamilton (BIB45) 2001; 8 Ahlstedt (BIB1) 2002; 32 Pauli (BIB25) 1998; 38 Hemmer, Focke, Kolarich, Wilson, Altmann, Wöhrl (BIB29) 2001; 108 Yeang (BIB28) 2000; 84 Hamilton, Brown (BIB40) 1999; 103 Fernández-Rivas, Van Ree, Cuevas (BIB7) 1997; 100 Witteman, Stapel, Perdok, Sjamsoedin, Jansen, Aalberse (BIB22) 1996; 97 Kulig, Bergmann, Klettke, Wahn, Tacke, Wahn (BIB38) 1999; 103 Halmerbauer, Hauk, Forster, Urbanek, Kaufmehl, Koller (BIB8) 1999; 10 Rancé, Abbal, Lauwers-Cancès (BIB35) 2002; 109 Pastorello, Farioli, Pravettoni, Ortolani, Ispano, Monza (BIB4) 1999; 103 Purohit, Laffer, Niederberger, Lieutier-Colas, De Blay (BIB23) 1–6 March, 2002, Poster n Roehr, Reibel, Ziegert, Sommerfeld, Wahn, Niggemann (BIB15) 2001; 107 Boyano-Martinez, Garcia-Ara, Diaz-Pena, Munoz, Garcia Sanchez, Martin-Esteban (BIB33) 2001; 31 Ballmer-Weber, Hoffmann, Wüthrich, Lüttkopf, Pompei, Wangorsch (BIB12) 2002; 57 Ylitalo, Alenius, Turjanmaa, Palosuo, Reunala (BIB41) 2000; 30 Pasini, Simonato, Curioni, Vincenzi, Cristaudo, Santucci (BIB13) 2002; 57 Ebner, Siemann, Bohle, Willheim, Wiedermann, Schenk (BIB18) 1997; 27 Ohashi, Nakai, Tanaka, Kakinoki, Washio, Kato (BIB21) 1998; 124 Aalberse (BIB27) 1998; 53 Jacobsen, Nuchel Petersen, Wihl, Lowenstein, Ipsen (BIB19) 1997; 52 Wolkerstorfer, Wahn, Kjellman, Diepgen, De Longueville, Oranje (BIB10) 2002; 32 Yunginger, Ahlstedt, Eggleston, Homburger, Nelson, Ownby (BIB3) 2000; 105 De Blay, Zana, Offner, Verot, Velten, Pauli (BIB42) 1993; 92 Sasai, Furukawa, Muto, Baba, Yabuta, Fukuwatari (BIB37) 1996; 128 Niederberger, Stubner, Spitzauer, Kraft, Valenta, Ehrenberger (BIB17) 2001; 117 Paganelli, Ansotegui, Sastre, Lange, Roovers, De Groot (BIB34) 1998; 53 Oehling, Sanz, Resano (BIB20) 1998; 8 Hill, Hosking, Reyes-Benito (BIB31) 2001; 31 Sampson (BIB2) 2001; 107 Sampson, Ho (BIB9) 1997; 100 Mari, Iacovacci, Afferni, Barletta, Tinghino, Di Felice (BIB26) 1999; 103 Pastorello, Vieths, Pravettoni, Farioli, Trambaioli, Fortunato (BIB14) 2002; 109 Plebani, Borghesan, Basso, Faggian (BIB46) 1996; 51 Sigurs, Hattevig, Kjellman, Kjellman, Nilsson, Bjorksten (BIB36) 1994; 94 Blanco, Diaz-Perales, Collada, Sanchez-Monge, Aragoncillo, Castillo (BIB5) 1999; 103 Lüttkopf, Ballmer-Weber, Wüthrich, Vieths (BIB11) 2000; 106 Hiller, Laffer, Harwanegg, Huber, Schmidt, Twardosz (BIB47) 2002; 16 Corey, Mamikoglu, Akbar, Houser, Gungor (BIB44) 2000; 122 Dolen (BIB43) 1994; 15 Sensi, Piacentini, Nobile, Ghebregzabher, Brunori, Zamolla (BIB39) 1994; 24 Thomas, Smith (BIB30) 2002; 32 Rancé, Dutau, Abbal (BIB16) 2000; 55 Guérin, Didierlaurent, Derer, Stadler (BIB24) 1985; 25 Wolkerstorfer (10.1016/S0923-2532(03)00047-4_BIB10) 2002; 32 Fernández-Rivas (10.1016/S0923-2532(03)00047-4_BIB7) 1997; 100 Hill (10.1016/S0923-2532(03)00047-4_BIB31) 2001; 31 Garcia-Ara (10.1016/S0923-2532(03)00047-4_BIB32) 2001; 107 Blanco (10.1016/S0923-2532(03)00047-4_BIB5) 1999; 103 Purohit (10.1016/S0923-2532(03)00047-4_BIB23) 2002 Thomas (10.1016/S0923-2532(03)00047-4_BIB30) 2002; 32 Halmerbauer (10.1016/S0923-2532(03)00047-4_BIB8) 1999; 10 Pasini (10.1016/S0923-2532(03)00047-4_BIB13) 2002; 57 Lüttkopf (10.1016/S0923-2532(03)00047-4_BIB11) 2000; 106 Guérin (10.1016/S0923-2532(03)00047-4_BIB24) 1985; 25 Sasai (10.1016/S0923-2532(03)00047-4_BIB37) 1996; 128 Jacobsen (10.1016/S0923-2532(03)00047-4_BIB19) 1997; 52 Yeang (10.1016/S0923-2532(03)00047-4_BIB28) 2000; 84 Kulig (10.1016/S0923-2532(03)00047-4_BIB38) 1999; 103 Pastorello (10.1016/S0923-2532(03)00047-4_BIB4) 1999; 103 Sampson (10.1016/S0923-2532(03)00047-4_BIB9) 1997; 100 De Blay (10.1016/S0923-2532(03)00047-4_BIB42) 1993; 92 Ylitalo (10.1016/S0923-2532(03)00047-4_BIB41) 2000; 30 Mari (10.1016/S0923-2532(03)00047-4_BIB26) 1999; 103 Paganelli (10.1016/S0923-2532(03)00047-4_BIB34) 1998; 53 Sensi (10.1016/S0923-2532(03)00047-4_BIB39) 1994; 24 Aalberse (10.1016/S0923-2532(03)00047-4_BIB27) 1998; 53 Ahlstedt (10.1016/S0923-2532(03)00047-4_BIB1) 2002; 32 Boyano-Martinez (10.1016/S0923-2532(03)00047-4_BIB33) 2001; 31 Rancé (10.1016/S0923-2532(03)00047-4_BIB16) 2000; 55 Yunginger (10.1016/S0923-2532(03)00047-4_BIB3) 2000; 105 Hiller (10.1016/S0923-2532(03)00047-4_BIB47) 2002; 16 Biagini (10.1016/S0923-2532(03)00047-4_BIB45) 2001; 8 Sigurs (10.1016/S0923-2532(03)00047-4_BIB36) 1994; 94 Ohashi (10.1016/S0923-2532(03)00047-4_BIB21) 1998; 124 Dolen (10.1016/S0923-2532(03)00047-4_BIB43) 1994; 15 Pauli (10.1016/S0923-2532(03)00047-4_BIB25) 1998; 38 Pastorello (10.1016/S0923-2532(03)00047-4_BIB14) 2002; 109 Corey (10.1016/S0923-2532(03)00047-4_BIB44) 2000; 122 Pastorello (10.1016/S0923-2532(03)00047-4_BIB6) 1999; 104 Hamilton (10.1016/S0923-2532(03)00047-4_BIB40) 1999; 103 Plebani (10.1016/S0923-2532(03)00047-4_BIB46) 1996; 51 Sampson (10.1016/S0923-2532(03)00047-4_BIB2) 2001; 107 Oehling (10.1016/S0923-2532(03)00047-4_BIB20) 1998; 8 Witteman (10.1016/S0923-2532(03)00047-4_BIB22) 1996; 97 Roehr (10.1016/S0923-2532(03)00047-4_BIB15) 2001; 107 Rancé (10.1016/S0923-2532(03)00047-4_BIB35) 2002; 109 Hemmer (10.1016/S0923-2532(03)00047-4_BIB29) 2001; 108 Niederberger (10.1016/S0923-2532(03)00047-4_BIB17) 2001; 117 Ballmer-Weber (10.1016/S0923-2532(03)00047-4_BIB12) 2002; 57 Ebner (10.1016/S0923-2532(03)00047-4_BIB18) 1997; 27 |
| References_xml | – volume: 103 start-page: 520 year: 1999 end-page: 526 ident: BIB4 article-title: The major allergen of peach (Prunus persica) is a lipid transfer protein publication-title: J Allergy Clin Immunol – year: 1–6 March, 2002, Poster n ident: BIB23 article-title: The discrepancy between quantitative IgE serology, skin test sensitivity and basophil releasability analysed with recombinant Bet v 1, the major birch pollen allergen – volume: 124 start-page: 1337 year: 1998 end-page: 1346 ident: BIB21 article-title: Serologic study of the working mechanisms of immunotherapy for children with perennial allergic rhinitis publication-title: Arch Otolaryngol Head Neck Surg – volume: 94 start-page: 757 year: 1994 end-page: 763 ident: BIB36 article-title: Appearance of atopic disease in relation to serum IgE antibodies in children followed up from birth for 4 to 15 years publication-title: J Allergy Clin Immunol – volume: 109 start-page: 1027 year: 2002 end-page: 1033 ident: BIB35 article-title: Improved screening for peanut allergy by the combined use of skin prick tests and specific IgE assays publication-title: J Allergy Clin Immunol – volume: 103 start-page: 507 year: 1999 end-page: 513 ident: BIB5 article-title: Class I chitinases as potential panallergens involved in the latex-fruit syndrome publication-title: J Allergy Clin Immunol – volume: 38 start-page: 13 year: 1998 end-page: 19 ident: BIB25 article-title: Allergènes et allergies croisées : implications présentes et futures publication-title: Rev Fr Allergol – volume: 92 start-page: 255 year: 1993 end-page: 263 ident: BIB42 article-title: Receiver operating characteristic analysis: a useful method for a comparison of the clinical relevance of two in vitro IgE tests publication-title: J Allergy Clin Immunol – volume: 55 start-page: 496 year: 2000 end-page: 500 ident: BIB16 article-title: Mustard allergy in children publication-title: Allergy – volume: 32 start-page: 11 year: 2002 end-page: 16 ident: BIB1 article-title: Understanding the usefulness of specific IgE blood tests in allergy publication-title: Clin Exp Allergy – volume: 32 start-page: 658 year: 2002 end-page: 661 ident: BIB30 article-title: How good are carbohydrates as allergens? publication-title: Clin Exp Allergy – volume: 8 start-page: 1145 year: 2001 end-page: 1149 ident: BIB45 article-title: Receiver operating characteristics analyses of Food and Drug Administration-cleared serological assays for natural rubber latex-specific immunoglobulin E antibody publication-title: Clin Diagn Lab Immunol – volume: 104 start-page: 1099 year: 1999 end-page: 1106 ident: BIB6 article-title: Clinical role of a lipid transfer protein that acts as a new apple-specific allergen publication-title: J Allergy Clin Immunol – volume: 106 start-page: 390 year: 2000 end-page: 399 ident: BIB11 article-title: Celery allergens in patients with positive double-blind placebo-controlled challenge publication-title: J Allergy Clin Immunol – volume: 103 start-page: 1005 year: 1999 end-page: 1011 ident: BIB26 article-title: Specific IgE to cross-reactive carbohydrate determinants strongly affects the in vitro diagnosis of allergic diseases publication-title: J Allergy Clin Immunol – volume: 51 start-page: 407 year: 1996 end-page: 411 ident: BIB46 article-title: Receiver-operating characteristic (ROC) curves: a fundamental tool for improving the clinical usefulness of in vitro IgE tests publication-title: Allergy – volume: 128 start-page: 834 year: 1996 end-page: 840 ident: BIB37 article-title: Early detection of specific IgE antibody against house dust mite in children at risk of allergic disease publication-title: J Pediatr – volume: 97 start-page: 16 year: 1996 end-page: 25 ident: BIB22 article-title: The relationship between RAST and skin test results in patients with asthma or rhinitis: a quantitative study with purified major allergens publication-title: J Allergy Clin Immunol – volume: 57 start-page: 228 year: 2002 end-page: 235 ident: BIB12 article-title: Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked celery in patients with celery allergy publication-title: Allergy – volume: 25 start-page: 189 year: 1985 end-page: 195 ident: BIB24 article-title: Seuil de positivité — Interprétation des résultats du RAST publication-title: Rev Fr Allergol – volume: 122 start-page: 64 year: 2000 end-page: 70 ident: BIB44 article-title: ImmunoCAP and HY publication-title: Otolaryngol Head Neck Surg – volume: 107 start-page: 891 year: 2001 end-page: 896 ident: BIB2 article-title: Utility of food-specific IgE concentrations in predicting symptomatic food allergy publication-title: J Allergy Clin Immunol – volume: 117 start-page: 848 year: 2001 end-page: 851 ident: BIB17 article-title: Skin test results but not serology reflect immediate type respiratory sensitivity: a study performed with recombinant allergen molecules publication-title: J Invest Dermatol – volume: 52 start-page: 914 year: 1997 end-page: 920 ident: BIB19 article-title: Immunotherapy with partially purified and standardized tree pollen extracts, IV. Results from long-term (6 year) follow-up publication-title: Allergy – volume: 16 start-page: 414 year: 2002 end-page: 416 ident: BIB47 article-title: Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment publication-title: FASEB J – volume: 53 start-page: 54 year: 1998 end-page: 57 ident: BIB27 article-title: Clinical relevance of carbohydrate allergen epitopes publication-title: Allergy – volume: 31 start-page: 1031 year: 2001 end-page: 1035 ident: BIB31 article-title: Reducing the need for food allergen challenges in young children: a comparison of in vitro with in vivo tests publication-title: Clin Exp Allergy – volume: 10 start-page: 53 year: 1999 end-page: 57 ident: BIB8 article-title: In vivo histamine release during the first minutes after deliberate sting challenges correlates with the severity of allergic symptoms publication-title: Pediatr Allergy Immunol – volume: 31 start-page: 1464 year: 2001 end-page: 1469 ident: BIB33 article-title: Validity of specific IgE antibodies in children with egg allergy publication-title: Clin Exp Allergy – volume: 108 start-page: 1045 year: 2001 end-page: 1052 ident: BIB29 article-title: Antibody binding to venom carbohydrates is a frequent cause for double positivity to honeybee and yellow jacket venom in patients with stinging-insect allergy publication-title: J Allergy Clin Immunol – volume: 53 start-page: 763 year: 1998 end-page: 768 ident: BIB34 article-title: Specific IgE antibodies in the diagnosis of atopic disease, Clinical evaluation of a new in vitro test system, UniCAP, in six European allergy clinics publication-title: Allergy – volume: 107 start-page: 185 year: 2001 end-page: 190 ident: BIB32 article-title: Specific IgE levels in the diagnosis of immediate hypersensitivity to cows' milk protein in the infant publication-title: J Allergy Clin Immunol – volume: 100 start-page: 728 year: 1997 end-page: 733 ident: BIB7 article-title: Allergy to Rosaceae fruits without related pollinosis publication-title: J Allergy Clin Immunol – volume: 8 start-page: 333 year: 1998 end-page: 339 ident: BIB20 article-title: Importance of IgG4 determination in in vitro immunotherapy follow-up of inhalant allergens publication-title: J Investig Allergol Clin Immunol – volume: 15 start-page: 319 year: 1994 end-page: 322 ident: BIB43 article-title: Detection limits and receiver operating characteristic curve analysis in the evaluation of specific IgE assays publication-title: Allergy Proc – volume: 105 start-page: 1077 year: 2000 end-page: 1084 ident: BIB3 article-title: Quantitative IgE antibody assays in allergic diseases publication-title: J Allergy Clin Immunol – volume: 32 start-page: 70 year: 2002 end-page: 73 ident: BIB10 article-title: Natural course of sensitization to cow’s milk and hen’s egg in childhood atopic dermatitis: ETAC Study Group publication-title: Clin Exp Allergy – volume: 109 start-page: 563 year: 2002 end-page: 570 ident: BIB14 article-title: Identification of hazelnut major allergens in sensitive patients with positive double-blind, placebo-controlled food challenge results publication-title: J Allergy Clin Immunol – volume: 107 start-page: 548 year: 2001 end-page: 553 ident: BIB15 article-title: Atopy patch tests, together with determination of IgE levels, reduce the need for oral food challenges in children with atopic dermatitis publication-title: J Allergy Clin Immunol – volume: 84 start-page: 628 year: 2000 end-page: 632 ident: BIB28 article-title: Prevalence of latex may be vastly overestimated when determined by in vitro assays publication-title: Ann Allergy Asthma Immunol – volume: 30 start-page: 1611 year: 2000 end-page: 1617 ident: BIB41 article-title: Natural rubber latex allergy in children: a follow-up study publication-title: Clin Exp Allergy – volume: 24 start-page: 331 year: 1994 end-page: 341 ident: BIB39 article-title: Changes in nasal specific IgE to mites after periods of allergen exposure avoidance: a comparison with serum levels publication-title: Clin Exp Allergy – volume: 57 start-page: 98 year: 2002 end-page: 106 ident: BIB13 article-title: IgE-mediated allergy to corn: a 50 kDa protein, belonging to the Reduced Soluble Proteins, is a major allergen publication-title: Allergy – volume: 27 start-page: 1007 year: 1997 end-page: 1015 ident: BIB18 article-title: Immunological changes during specific immunotherapy of grass pollen allergy: reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T-cell clones specific for Phl p 1, a major grass pollen allergen publication-title: Clin Exp Allergy – volume: 100 start-page: 444 year: 1997 end-page: 451 ident: BIB9 article-title: Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents publication-title: J Allergy Clin Immunol – volume: 103 start-page: S52 year: 1999 ident: BIB40 article-title: Natural history of latex allergy in sensitized healthcare workers (HCWs) publication-title: J Allergy Clin Immunol – volume: 103 start-page: 1173 year: 1999 end-page: 1179 ident: BIB38 article-title: Natural course of sensitization to food and inhalant allergens during the first 6 years of life publication-title: J Allergy Clin Immunol – volume: 32 start-page: 11 year: 2002 ident: 10.1016/S0923-2532(03)00047-4_BIB1 article-title: Understanding the usefulness of specific IgE blood tests in allergy publication-title: Clin Exp Allergy doi: 10.1046/j.0022-0477.2001.01289.x – volume: 105 start-page: 1077 year: 2000 ident: 10.1016/S0923-2532(03)00047-4_BIB3 article-title: Quantitative IgE antibody assays in allergic diseases publication-title: J Allergy Clin Immunol doi: 10.1067/mai.2000.107041 – volume: 25 start-page: 189 year: 1985 ident: 10.1016/S0923-2532(03)00047-4_BIB24 article-title: Seuil de positivité — Interprétation des résultats du RAST publication-title: Rev Fr Allergol – volume: 107 start-page: 185 year: 2001 ident: 10.1016/S0923-2532(03)00047-4_BIB32 article-title: Specific IgE levels in the diagnosis of immediate hypersensitivity to cows' milk protein in the infant publication-title: J Allergy Clin Immunol doi: 10.1067/mai.2001.111592 – volume: 109 start-page: 563 year: 2002 ident: 10.1016/S0923-2532(03)00047-4_BIB14 article-title: Identification of hazelnut major allergens in sensitive patients with positive double-blind, placebo-controlled food challenge results publication-title: J Allergy Clin Immunol doi: 10.1067/mai.2002.121946 – volume: 117 start-page: 848 year: 2001 ident: 10.1016/S0923-2532(03)00047-4_BIB17 article-title: Skin test results but not serology reflect immediate type respiratory sensitivity: a study performed with recombinant allergen molecules publication-title: J Invest Dermatol doi: 10.1046/j.0022-202x.2001.01470.x – volume: 103 start-page: 520 year: 1999 ident: 10.1016/S0923-2532(03)00047-4_BIB4 article-title: The major allergen of peach (Prunus persica) is a lipid transfer protein publication-title: J Allergy Clin Immunol doi: 10.1016/S0091-6749(99)70480-X – volume: 52 start-page: 914 year: 1997 ident: 10.1016/S0923-2532(03)00047-4_BIB19 article-title: Immunotherapy with partially purified and standardized tree pollen extracts, IV. Results from long-term (6 year) follow-up publication-title: Allergy doi: 10.1111/j.1398-9995.1997.tb01251.x – volume: 10 start-page: 53 year: 1999 ident: 10.1016/S0923-2532(03)00047-4_BIB8 article-title: In vivo histamine release during the first minutes after deliberate sting challenges correlates with the severity of allergic symptoms publication-title: Pediatr Allergy Immunol doi: 10.1034/j.1399-3038.1999.101012.x – volume: 27 start-page: 1007 year: 1997 ident: 10.1016/S0923-2532(03)00047-4_BIB18 article-title: Immunological changes during specific immunotherapy of grass pollen allergy: reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T-cell clones specific for Phl p 1, a major grass pollen allergen publication-title: Clin Exp Allergy doi: 10.1111/j.1365-2222.1997.tb01252.x – year: 2002 ident: 10.1016/S0923-2532(03)00047-4_BIB23 article-title: The discrepancy between quantitative IgE serology, skin test sensitivity and basophil releasability analysed with recombinant Bet v 1, the major birch pollen allergen doi: 10.1016/S0091-6749(02)81445-2 – volume: 107 start-page: 548 year: 2001 ident: 10.1016/S0923-2532(03)00047-4_BIB15 article-title: Atopy patch tests, together with determination of IgE levels, reduce the need for oral food challenges in children with atopic dermatitis publication-title: J Allergy Clin Immunol doi: 10.1067/mai.2001.112849 – volume: 24 start-page: 331 year: 1994 ident: 10.1016/S0923-2532(03)00047-4_BIB39 article-title: Changes in nasal specific IgE to mites after periods of allergen exposure avoidance: a comparison with serum levels publication-title: Clin Exp Allergy doi: 10.1111/j.1365-2222.1994.tb00250.x – volume: 15 start-page: 319 year: 1994 ident: 10.1016/S0923-2532(03)00047-4_BIB43 article-title: Detection limits and receiver operating characteristic curve analysis in the evaluation of specific IgE assays publication-title: Allergy Proc doi: 10.2500/108854194778816508 – volume: 100 start-page: 444 year: 1997 ident: 10.1016/S0923-2532(03)00047-4_BIB9 article-title: Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents publication-title: J Allergy Clin Immunol doi: 10.1016/S0091-6749(97)70133-7 – volume: 84 start-page: 628 year: 2000 ident: 10.1016/S0923-2532(03)00047-4_BIB28 article-title: Prevalence of latex may be vastly overestimated when determined by in vitro assays publication-title: Ann Allergy Asthma Immunol doi: 10.1016/S1081-1206(10)62415-5 – volume: 124 start-page: 1337 year: 1998 ident: 10.1016/S0923-2532(03)00047-4_BIB21 article-title: Serologic study of the working mechanisms of immunotherapy for children with perennial allergic rhinitis publication-title: Arch Otolaryngol Head Neck Surg doi: 10.1001/archotol.124.12.1337 – volume: 109 start-page: 1027 year: 2002 ident: 10.1016/S0923-2532(03)00047-4_BIB35 article-title: Improved screening for peanut allergy by the combined use of skin prick tests and specific IgE assays publication-title: J Allergy Clin Immunol doi: 10.1067/mai.2002.124775 – volume: 51 start-page: 407 year: 1996 ident: 10.1016/S0923-2532(03)00047-4_BIB46 article-title: Receiver-operating characteristic (ROC) curves: a fundamental tool for improving the clinical usefulness of in vitro IgE tests publication-title: Allergy doi: 10.1111/j.1398-9995.1996.tb00150.x – volume: 92 start-page: 255 year: 1993 ident: 10.1016/S0923-2532(03)00047-4_BIB42 article-title: Receiver operating characteristic analysis: a useful method for a comparison of the clinical relevance of two in vitro IgE tests publication-title: J Allergy Clin Immunol doi: 10.1016/0091-6749(93)90169-G – volume: 31 start-page: 1031 year: 2001 ident: 10.1016/S0923-2532(03)00047-4_BIB31 article-title: Reducing the need for food allergen challenges in young children: a comparison of in vitro with in vivo tests publication-title: Clin Exp Allergy doi: 10.1046/j.1365-2222.2001.01113.x – volume: 103 start-page: 507 year: 1999 ident: 10.1016/S0923-2532(03)00047-4_BIB5 article-title: Class I chitinases as potential panallergens involved in the latex-fruit syndrome publication-title: J Allergy Clin Immunol doi: 10.1016/S0091-6749(99)70478-1 – volume: 57 start-page: 228 year: 2002 ident: 10.1016/S0923-2532(03)00047-4_BIB12 article-title: Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked celery in patients with celery allergy publication-title: Allergy doi: 10.1034/j.1398-9995.2002.1o3319.x – volume: 30 start-page: 1611 year: 2000 ident: 10.1016/S0923-2532(03)00047-4_BIB41 article-title: Natural rubber latex allergy in children: a follow-up study publication-title: Clin Exp Allergy doi: 10.1046/j.1365-2222.2000.00924.x – volume: 106 start-page: 390 year: 2000 ident: 10.1016/S0923-2532(03)00047-4_BIB11 article-title: Celery allergens in patients with positive double-blind placebo-controlled challenge publication-title: J Allergy Clin Immunol doi: 10.1067/mai.2000.108711 – volume: 108 start-page: 1045 year: 2001 ident: 10.1016/S0923-2532(03)00047-4_BIB29 article-title: Antibody binding to venom carbohydrates is a frequent cause for double positivity to honeybee and yellow jacket venom in patients with stinging-insect allergy publication-title: J Allergy Clin Immunol doi: 10.1067/mai.2001.120013 – volume: 31 start-page: 1464 year: 2001 ident: 10.1016/S0923-2532(03)00047-4_BIB33 article-title: Validity of specific IgE antibodies in children with egg allergy publication-title: Clin Exp Allergy doi: 10.1046/j.1365-2222.2001.01175.x – volume: 8 start-page: 1145 year: 2001 ident: 10.1016/S0923-2532(03)00047-4_BIB45 article-title: Receiver operating characteristics analyses of Food and Drug Administration-cleared serological assays for natural rubber latex-specific immunoglobulin E antibody publication-title: Clin Diagn Lab Immunol doi: 10.1128/CDLI.8.6.1145-1149.2001 – volume: 97 start-page: 16 year: 1996 ident: 10.1016/S0923-2532(03)00047-4_BIB22 article-title: The relationship between RAST and skin test results in patients with asthma or rhinitis: a quantitative study with purified major allergens publication-title: J Allergy Clin Immunol doi: 10.1016/S0091-6749(96)70278-6 – volume: 53 start-page: 54 issue: Suppl. 45 year: 1998 ident: 10.1016/S0923-2532(03)00047-4_BIB27 article-title: Clinical relevance of carbohydrate allergen epitopes publication-title: Allergy doi: 10.1111/j.1398-9995.1998.tb04940.x – volume: 104 start-page: 1099 year: 1999 ident: 10.1016/S0923-2532(03)00047-4_BIB6 article-title: Clinical role of a lipid transfer protein that acts as a new apple-specific allergen publication-title: J Allergy Clin Immunol doi: 10.1016/S0091-6749(99)70095-3 – volume: 32 start-page: 70 year: 2002 ident: 10.1016/S0923-2532(03)00047-4_BIB10 article-title: Natural course of sensitization to cow’s milk and hen’s egg in childhood atopic dermatitis: ETAC Study Group publication-title: Clin Exp Allergy doi: 10.1046/j.0022-0477.2001.01265.x – volume: 57 start-page: 98 year: 2002 ident: 10.1016/S0923-2532(03)00047-4_BIB13 article-title: IgE-mediated allergy to corn: a 50 kDa protein, belonging to the Reduced Soluble Proteins, is a major allergen publication-title: Allergy doi: 10.1034/j.1398-9995.2002.1o3413.x – volume: 100 start-page: 728 year: 1997 ident: 10.1016/S0923-2532(03)00047-4_BIB7 article-title: Allergy to Rosaceae fruits without related pollinosis publication-title: J Allergy Clin Immunol doi: 10.1016/S0091-6749(97)70265-3 – volume: 107 start-page: 891 year: 2001 ident: 10.1016/S0923-2532(03)00047-4_BIB2 article-title: Utility of food-specific IgE concentrations in predicting symptomatic food allergy publication-title: J Allergy Clin Immunol doi: 10.1067/mai.2001.114708 – volume: 32 start-page: 658 year: 2002 ident: 10.1016/S0923-2532(03)00047-4_BIB30 article-title: How good are carbohydrates as allergens? publication-title: Clin Exp Allergy doi: 10.1046/j.1365-2222.2002.01396.x – volume: 103 start-page: S52 year: 1999 ident: 10.1016/S0923-2532(03)00047-4_BIB40 article-title: Natural history of latex allergy in sensitized healthcare workers (HCWs) publication-title: J Allergy Clin Immunol – volume: 103 start-page: 1173 year: 1999 ident: 10.1016/S0923-2532(03)00047-4_BIB38 article-title: Natural course of sensitization to food and inhalant allergens during the first 6 years of life publication-title: J Allergy Clin Immunol doi: 10.1016/S0091-6749(99)70195-8 – volume: 38 start-page: 13 year: 1998 ident: 10.1016/S0923-2532(03)00047-4_BIB25 article-title: Allergènes et allergies croisées : implications présentes et futures publication-title: Rev Fr Allergol – volume: 94 start-page: 757 year: 1994 ident: 10.1016/S0923-2532(03)00047-4_BIB36 article-title: Appearance of atopic disease in relation to serum IgE antibodies in children followed up from birth for 4 to 15 years publication-title: J Allergy Clin Immunol doi: 10.1016/0091-6749(94)90184-8 – volume: 16 start-page: 414 year: 2002 ident: 10.1016/S0923-2532(03)00047-4_BIB47 article-title: Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment publication-title: FASEB J doi: 10.1096/fj.01-0711fje – volume: 103 start-page: 1005 year: 1999 ident: 10.1016/S0923-2532(03)00047-4_BIB26 article-title: Specific IgE to cross-reactive carbohydrate determinants strongly affects the in vitro diagnosis of allergic diseases publication-title: J Allergy Clin Immunol doi: 10.1016/S0091-6749(99)70171-5 – volume: 53 start-page: 763 year: 1998 ident: 10.1016/S0923-2532(03)00047-4_BIB34 article-title: Specific IgE antibodies in the diagnosis of atopic disease, Clinical evaluation of a new in vitro test system, UniCAP, in six European allergy clinics publication-title: Allergy doi: 10.1111/j.1398-9995.1998.tb03972.x – volume: 55 start-page: 496 year: 2000 ident: 10.1016/S0923-2532(03)00047-4_BIB16 article-title: Mustard allergy in children publication-title: Allergy doi: 10.1034/j.1398-9995.2000.00383.x – volume: 8 start-page: 333 year: 1998 ident: 10.1016/S0923-2532(03)00047-4_BIB20 article-title: Importance of IgG4 determination in in vitro immunotherapy follow-up of inhalant allergens publication-title: J Investig Allergol Clin Immunol – volume: 128 start-page: 834 year: 1996 ident: 10.1016/S0923-2532(03)00047-4_BIB37 article-title: Early detection of specific IgE antibody against house dust mite in children at risk of allergic disease publication-title: J Pediatr doi: 10.1016/S0022-3476(96)70337-2 – volume: 122 start-page: 64 year: 2000 ident: 10.1016/S0923-2532(03)00047-4_BIB44 article-title: ImmunoCAP and HY*TEC enzyme immunoassays in the detection of allergen-specific IgE compared with serial skin end-point titration by receiver operating characteristic analysis publication-title: Otolaryngol Head Neck Surg doi: 10.1016/S0194-5998(00)70146-X |
| SSID | ssj0021040 |
| Score | 1.5106171 |
| Snippet | Les explorations in vitro en allergie ont recours principalement aux dosages des IgE « spécifiques » (IgE-S). Ces tests sont souvent dénommés RASTs et leurs... |
| SourceID | pascalfrancis crossref elsevier |
| SourceType | Index Database Enrichment Source Publisher |
| StartPage | 144 |
| SubjectTerms | Allergie Allergy Courbes de risque Diagnosis Diagnostic IgE spécifiques Immunopathologie Interprétation des résultats Méthodes immunologiques de diagnostic et d'exploration Result interpretation Risk curves Sciences biologiques et medicales Sciences medicales Specific IgE Tests sérologiques |
| Title | Quelle valeur clinique accorder aux résultats chiffrés des dosages d'IgE spécifiques ? |
| URI | https://dx.doi.org/10.1016/S0923-2532(03)00047-4 |
| Volume | 18 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1878-1365 dateEnd: 20131231 omitProxy: false ssIdentifier: ssj0021040 issn: 0923-2532 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lj9MwELagCxISQjzF8lj5QAUoCiSxEzsnVKEiyqECsUjlFDl-oJVWbZQ0qPyk_R37xxjHTtNdtCocODRN3diWPF9sz3jmG4Re5JGlxUpJqJnQIU1jHnKl0jCSEaFSSJWXpks2weZzvljkn_2JadOlE2DLJd9s8uq_ihrKQNg2dPYfxL1tFArgHoQOVxA7XP9K8F9aa4sPoEnd1i7y0VK0Cik7ms1AtJvAn4837SnsNRsb0W1MXxYoDZ-VdTiD73HCZj-mQVO5f60Hn11JgksOgTMbZrIKRUdxojs8OXqnE71T15ItuvvB43ZiU3ZMZvMhUKK3QZDBJObX7127YkLCJCVXTLGDBt7Nl7Ejf_RLb-y4Z_-Y1Z2B4eu26bFNqTVObL5TynyQ0AUm7Usr3NbvMKYs5xmn19FBwkCVGqGDyWy6-LRV0UE57axyfU9DzNfboftXEXntu75qN3O7Eg28Y8YlR9nZsRzfRXe8qoEnDiL30DVT30c3XfLRXw_QdwcU7ICCe6DgHigYgILr8zMPEuxAAr8xAAR7gGD1EuCBm-r8rIcGfvcQffswPX7_MfSJNkKZpMk61PY4XWRcCcEl4dKmIc9FLKNcs0xRoXlJSskJK2VMjDAR0USXXJvMSMJ0RB6h0XK11I8RNhktMxUbeM85JYLn2hBlSqZIBqpyEh0i2g9YIT0LvU2GcloM7oYwzoUd5yIiRTfOBT1Eb7bVKkfDsq8C76VR-L2k2yMWAKp9VY8uSG_o0KPnyb4HnqJbnc9nZ6l7hkbrutXP0Q35c33S1Ecec78BMvuWeg |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Quelle+valeur+clinique+accorder+aux+r%C3%A9sultats+chiffr%C3%A9s+des+dosages+d%27IgE+sp%C3%A9cifiques+%3F&rft.jtitle=Immuno-analyse+%26+biologie+sp%C3%A9cialis%C3%A9e&rft.au=MALANDAIN%2C+H&rft.date=2003&rft.pub=Elsevier&rft.issn=0923-2532&rft.volume=18&rft.issue=3&rft.spage=144&rft.epage=151&rft_id=info:doi/10.1016%2FS0923-2532%2803%2900047-4&rft.externalDBID=n%2Fa&rft.externalDocID=14798684 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0923-2532&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0923-2532&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0923-2532&client=summon |