Long-Term Safety of Tofacitinib for Treatment of Moderate-to-Severe Ulcerative Colitis: Three Years of Korean National Data
Ulcerative colitis (UC) requires long-term treatment. Tofacitinib, a JAK inhibitor approved for UC, raises safety concerns regarding serious adverse events (SAEs) such as thromboembolism, major adverse cardiovascular events (MACEs), and opportunistic infections. This study aimed to evaluate the long...
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| Vydáno v: | Journal of Korean medical science Ročník 40; číslo 39; s. e259 - 9 |
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| Jazyk: | angličtina |
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Korea (South)
대한의학회
13.10.2025
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| ISSN: | 1011-8934, 1598-6357, 1598-6357 |
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| Abstract | Ulcerative colitis (UC) requires long-term treatment. Tofacitinib, a JAK inhibitor approved for UC, raises safety concerns regarding serious adverse events (SAEs) such as thromboembolism, major adverse cardiovascular events (MACEs), and opportunistic infections. This study aimed to evaluate the long-term safety of tofacitinib versus anti-tumor necrosis factor (TNF) inhibitors in Korean patients with UC using a nationwide population-based cohort.
We analyzed data from the National Health Insurance Service database from May 2019 to April 2022. Patients with UC were identified using the International Classification of Diseases, 10th revision and rare intractable disease codes. We compared the incidence of SAEs, including MACE, thromboembolic events, herpes zoster, tuberculosis, and malignancy, between the tofacitinib and anti-TNF inhibitor groups. The risk factors for SAEs in all patients with UC and tofacitinib users were also analyzed.
A total of 1,816 patients with UC were included (521 treated with tofacitinib and 1,295 treated with anti-TNF inhibitors). The overall incidence of SAEs was similar between the tofacitinib and anti-TNF inhibitor groups (4.41/100 person-years vs. 5.33/100 person-years,
= 0.332). Thromboembolic events, including MACE, pulmonary thromboembolism, and deep vein thrombosis, were comparable between the two groups (
= 0.151). The incidence of opportunistic infections (herpes zoster and tuberculosis) and malignancy did not differ significantly between the two groups. Among tofacitinib users, older age (≥ 60 years) and concomitant hypertension were significant risk factors for SAEs.
Tofacitinib demonstrates a safety profile comparable to that of anti-TNF inhibitors in Korean patients with UC. Despite safety concerns, tofacitinib can be safely used in this population with caution in older patients and those with comorbidities. |
|---|---|
| AbstractList | Background: Ulcerative colitis (UC) requires long-term treatment. Tofacitinib, a JAK inhibitor approved for UC, raises safety concerns regarding serious adverse events (SAEs) such as thromboembolism, major adverse cardiovascular events (MACEs), and opportunistic infections. This study aimed to evaluate the long-term safety of tofacitinib versus anti-tumor necrosis factor (TNF) inhibitors in Korean patients with UC using a nationwide populationbased cohort.
Methods: We analyzed data from the National Health Insurance Service database from May 2019 to April 2022. Patients with UC were identified using the International Classification of Diseases, 10th revision and rare intractable disease codes. We compared the incidence of SAEs, including MACE, thromboembolic events, herpes zoster, tuberculosis, and malignancy, between the tofacitinib and anti-TNF inhibitor groups. The risk factors for SAEs in all patients with UC and tofacitinib users were also analyzed.
Results: A total of 1,816 patients with UC were included (521 treated with tofacitinib and 1,295 treated with anti-TNF inhibitors). The overall incidence of SAEs was similar between the tofacitinib and anti-TNF inhibitor groups (4.41/100 person-years vs. 5.33/100 personyears, P = 0.332). Thromboembolic events, including MACE, pulmonary thromboembolism, and deep vein thrombosis, were comparable between the two groups (P = 0.151).
The incidence of opportunistic infections (herpes zoster and tuberculosis) and malignancy did not differ significantly between the two groups. Among tofacitinib users, older age (≥ 60 years) and concomitant hypertension were significant risk factors for SAEs.
Conclusion: Tofacitinib demonstrates a safety profile comparable to that of anti-TNF inhibitors in Korean patients with UC. Despite safety concerns, tofacitinib can be safely used in this population with caution in older patients and those with comorbidities. KCI Citation Count: 0 Ulcerative colitis (UC) requires long-term treatment. Tofacitinib, a JAK inhibitor approved for UC, raises safety concerns regarding serious adverse events (SAEs) such as thromboembolism, major adverse cardiovascular events (MACEs), and opportunistic infections. This study aimed to evaluate the long-term safety of tofacitinib versus anti-tumor necrosis factor (TNF) inhibitors in Korean patients with UC using a nationwide population-based cohort. We analyzed data from the National Health Insurance Service database from May 2019 to April 2022. Patients with UC were identified using the International Classification of Diseases, 10th revision and rare intractable disease codes. We compared the incidence of SAEs, including MACE, thromboembolic events, herpes zoster, tuberculosis, and malignancy, between the tofacitinib and anti-TNF inhibitor groups. The risk factors for SAEs in all patients with UC and tofacitinib users were also analyzed. A total of 1,816 patients with UC were included (521 treated with tofacitinib and 1,295 treated with anti-TNF inhibitors). The overall incidence of SAEs was similar between the tofacitinib and anti-TNF inhibitor groups (4.41/100 person-years vs. 5.33/100 person-years, = 0.332). Thromboembolic events, including MACE, pulmonary thromboembolism, and deep vein thrombosis, were comparable between the two groups ( = 0.151). The incidence of opportunistic infections (herpes zoster and tuberculosis) and malignancy did not differ significantly between the two groups. Among tofacitinib users, older age (≥ 60 years) and concomitant hypertension were significant risk factors for SAEs. Tofacitinib demonstrates a safety profile comparable to that of anti-TNF inhibitors in Korean patients with UC. Despite safety concerns, tofacitinib can be safely used in this population with caution in older patients and those with comorbidities. Ulcerative colitis (UC) requires long-term treatment. Tofacitinib, a JAK inhibitor approved for UC, raises safety concerns regarding serious adverse events (SAEs) such as thromboembolism, major adverse cardiovascular events (MACEs), and opportunistic infections. This study aimed to evaluate the long-term safety of tofacitinib versus anti-tumor necrosis factor (TNF) inhibitors in Korean patients with UC using a nationwide population-based cohort.BACKGROUNDUlcerative colitis (UC) requires long-term treatment. Tofacitinib, a JAK inhibitor approved for UC, raises safety concerns regarding serious adverse events (SAEs) such as thromboembolism, major adverse cardiovascular events (MACEs), and opportunistic infections. This study aimed to evaluate the long-term safety of tofacitinib versus anti-tumor necrosis factor (TNF) inhibitors in Korean patients with UC using a nationwide population-based cohort.We analyzed data from the National Health Insurance Service database from May 2019 to April 2022. Patients with UC were identified using the International Classification of Diseases, 10th revision and rare intractable disease codes. We compared the incidence of SAEs, including MACE, thromboembolic events, herpes zoster, tuberculosis, and malignancy, between the tofacitinib and anti-TNF inhibitor groups. The risk factors for SAEs in all patients with UC and tofacitinib users were also analyzed.METHODSWe analyzed data from the National Health Insurance Service database from May 2019 to April 2022. Patients with UC were identified using the International Classification of Diseases, 10th revision and rare intractable disease codes. We compared the incidence of SAEs, including MACE, thromboembolic events, herpes zoster, tuberculosis, and malignancy, between the tofacitinib and anti-TNF inhibitor groups. The risk factors for SAEs in all patients with UC and tofacitinib users were also analyzed.A total of 1,816 patients with UC were included (521 treated with tofacitinib and 1,295 treated with anti-TNF inhibitors). The overall incidence of SAEs was similar between the tofacitinib and anti-TNF inhibitor groups (4.41/100 person-years vs. 5.33/100 person-years, P = 0.332). Thromboembolic events, including MACE, pulmonary thromboembolism, and deep vein thrombosis, were comparable between the two groups (P = 0.151). The incidence of opportunistic infections (herpes zoster and tuberculosis) and malignancy did not differ significantly between the two groups. Among tofacitinib users, older age (≥ 60 years) and concomitant hypertension were significant risk factors for SAEs.RESULTSA total of 1,816 patients with UC were included (521 treated with tofacitinib and 1,295 treated with anti-TNF inhibitors). The overall incidence of SAEs was similar between the tofacitinib and anti-TNF inhibitor groups (4.41/100 person-years vs. 5.33/100 person-years, P = 0.332). Thromboembolic events, including MACE, pulmonary thromboembolism, and deep vein thrombosis, were comparable between the two groups (P = 0.151). The incidence of opportunistic infections (herpes zoster and tuberculosis) and malignancy did not differ significantly between the two groups. Among tofacitinib users, older age (≥ 60 years) and concomitant hypertension were significant risk factors for SAEs.Tofacitinib demonstrates a safety profile comparable to that of anti-TNF inhibitors in Korean patients with UC. Despite safety concerns, tofacitinib can be safely used in this population with caution in older patients and those with comorbidities.CONCLUSIONTofacitinib demonstrates a safety profile comparable to that of anti-TNF inhibitors in Korean patients with UC. Despite safety concerns, tofacitinib can be safely used in this population with caution in older patients and those with comorbidities. |
| Author | Song, Eun Mi Seo, Gi Hyeon Jung, Sung Hoon |
| Author_xml | – sequence: 1 givenname: Eun Mi orcidid: 0000-0002-2428-1551 surname: Song fullname: Song, Eun Mi organization: Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea – sequence: 2 givenname: Gi Hyeon orcidid: 0000-0001-7414-0258 surname: Seo fullname: Seo, Gi Hyeon organization: Department of Healthcare Review and Assessment Committee, Health Insurance Review and Assessment Service, Wonju, Korea – sequence: 3 givenname: Sung Hoon orcidid: 0000-0001-9075-2027 surname: Jung fullname: Jung, Sung Hoon organization: Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea |
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| Cites_doi | 10.5009/gnl210190 10.1038/ajg.2011.60 10.1016/j.crohns.2010.04.004 10.1136/ard-2022-222259 10.1055/s-0037-1615600 10.1016/j.cgh.2018.05.024 10.1053/j.gastro.2020.01.001 10.1021/jm1004286 10.5217/ir.2020.00121 10.1016/j.thromres.2012.05.025 10.1111/apt.15514 10.1093/ibd/izy058 10.1002/bjs.4454 10.1016/j.cgh.2018.11.035 10.1056/NEJMoa2109927 10.1038/gene.2014.51 10.5217/ir.2018.00096 10.1097/MIB.0b013e3182a19268 10.1111/apt.17509 10.1016/j.cgh.2020.10.004 10.1111/apt.16712 10.1111/jgh.15923 10.1016/j.thromres.2014.12.025 |
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| Keywords | Cardiovascular Diseases Tofacitinib Ulcerative Colitis Infections Inflammatory Bowel Disease Safety Thromboembolism Korea |
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| References | Hong (10.3346/jkms.2025.40.e259_ref2) 2020; 18 Olivera (10.3346/jkms.2025.40.e259_ref7) 2023; 57 Buisson (10.3346/jkms.2025.40.e259_ref5) 2013; 19 Colombel (10.3346/jkms.2025.40.e259_ref8) 2022; 20 Matsuoka (10.3346/jkms.2025.40.e259_ref22) 2022; 37 Crosslin (10.3346/jkms.2025.40.e259_ref24) 2015; 16 Allez (10.3346/jkms.2025.40.e259_ref3) 2010; 4 Charles-Schoeman (10.3346/jkms.2025.40.e259_ref14) 2023; 82 Cohen (10.3346/jkms.2025.40.e259_ref16) 2012; 130 Huang (10.3346/jkms.2025.40.e259_ref17) 2016; 15 Sandborn (10.3346/jkms.2025.40.e259_ref11) 2019; 17 Marin (10.3346/jkms.2025.40.e259_ref25) 2010; 59 Olivera (10.3346/jkms.2025.40.e259_ref10) 2020; 158 Chang (10.3346/jkms.2025.40.e259_ref23) 2018; 16 Sandborn (10.3346/jkms.2025.40.e259_ref9) 2022; 55 Ytterberg (10.3346/jkms.2025.40.e259_ref13) 2022; 386 Kim (10.3346/jkms.2025.40.e259_ref19) 2022; 16 Flanagan (10.3346/jkms.2025.40.e259_ref6) 2010; 53 Bernstein (10.3346/jkms.2025.40.e259_ref21) 2001; 85 Yen (10.3346/jkms.2025.40.e259_ref1) 2019; 17 Cheuk (10.3346/jkms.2025.40.e259_ref15) 2004; 91 Weng (10.3346/jkms.2025.40.e259_ref18) 2018; 24 Billioud (10.3346/jkms.2025.40.e259_ref4) 2011; 106 Chung (10.3346/jkms.2025.40.e259_ref20) 2015; 135 Sandborn (10.3346/jkms.2025.40.e259_ref12) 2019; 50 |
| References_xml | – volume: 16 start-page: 555 issue: 4 year: 2022 ident: 10.3346/jkms.2025.40.e259_ref19 publication-title: Gut Liver doi: 10.5009/gnl210190 – volume: 106 start-page: 674 issue: 4 year: 2011 ident: 10.3346/jkms.2025.40.e259_ref4 publication-title: Am J Gastroenterol doi: 10.1038/ajg.2011.60 – volume: 4 start-page: 355 issue: 4 year: 2010 ident: 10.3346/jkms.2025.40.e259_ref3 publication-title: J Crohn’s Colitis doi: 10.1016/j.crohns.2010.04.004 – volume: 82 start-page: 119 issue: 1 year: 2023 ident: 10.3346/jkms.2025.40.e259_ref14 publication-title: Ann Rheum Dis doi: 10.1136/ard-2022-222259 – volume: 85 start-page: 430 issue: 3 year: 2001 ident: 10.3346/jkms.2025.40.e259_ref21 publication-title: Thromb Haemost doi: 10.1055/s-0037-1615600 – volume: 16 start-page: 1928 issue: 12 year: 2018 ident: 10.3346/jkms.2025.40.e259_ref23 publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2018.05.024 – volume: 158 start-page: 1554 issue: 6 year: 2020 ident: 10.3346/jkms.2025.40.e259_ref10 publication-title: Gastroenterology doi: 10.1053/j.gastro.2020.01.001 – volume: 15 start-page: 15017644 issue: 1 year: 2016 ident: 10.3346/jkms.2025.40.e259_ref17 publication-title: Genet Mol Res – volume: 53 start-page: 8468 issue: 24 year: 2010 ident: 10.3346/jkms.2025.40.e259_ref6 publication-title: J Med Chem doi: 10.1021/jm1004286 – volume: 18 start-page: 345 issue: 4 year: 2020 ident: 10.3346/jkms.2025.40.e259_ref2 publication-title: Intest Res doi: 10.5217/ir.2020.00121 – volume: 130 start-page: 291 issue: 3 year: 2012 ident: 10.3346/jkms.2025.40.e259_ref16 publication-title: Thromb Res doi: 10.1016/j.thromres.2012.05.025 – volume: 50 start-page: 1068 issue: 10 year: 2019 ident: 10.3346/jkms.2025.40.e259_ref12 publication-title: Aliment Pharmacol Ther doi: 10.1111/apt.15514 – volume: 24 start-page: 1791 issue: 8 year: 2018 ident: 10.3346/jkms.2025.40.e259_ref18 publication-title: Inflamm Bowel Dis doi: 10.1093/ibd/izy058 – volume: 91 start-page: 424 issue: 4 year: 2004 ident: 10.3346/jkms.2025.40.e259_ref15 publication-title: Br J Surg doi: 10.1002/bjs.4454 – volume: 17 start-page: 1541 issue: 8 year: 2019 ident: 10.3346/jkms.2025.40.e259_ref11 publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2018.11.035 – volume: 386 start-page: 316 issue: 4 year: 2022 ident: 10.3346/jkms.2025.40.e259_ref13 publication-title: N Engl J Med doi: 10.1056/NEJMoa2109927 – volume: 16 start-page: 1 issue: 1 year: 2015 ident: 10.3346/jkms.2025.40.e259_ref24 publication-title: Genes Immun doi: 10.1038/gene.2014.51 – volume: 17 start-page: 54 issue: 1 year: 2019 ident: 10.3346/jkms.2025.40.e259_ref1 publication-title: Intest Res doi: 10.5217/ir.2018.00096 – volume: 19 start-page: 2464 issue: 11 year: 2013 ident: 10.3346/jkms.2025.40.e259_ref5 publication-title: Inflamm Bowel Dis doi: 10.1097/MIB.0b013e3182a19268 – volume: 57 start-page: 1231 issue: 11 year: 2023 ident: 10.3346/jkms.2025.40.e259_ref7 publication-title: Aliment Pharmacol Ther doi: 10.1111/apt.17509 – volume: 20 start-page: 116 issue: 1 year: 2022 ident: 10.3346/jkms.2025.40.e259_ref8 publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2020.10.004 – volume: 55 start-page: 464 issue: 4 year: 2022 ident: 10.3346/jkms.2025.40.e259_ref9 publication-title: Aliment Pharmacol Ther doi: 10.1111/apt.16712 – volume: 37 start-page: 1884 issue: 10 year: 2022 ident: 10.3346/jkms.2025.40.e259_ref22 publication-title: J Gastroenterol Hepatol doi: 10.1111/jgh.15923 – volume: 135 start-page: 492 issue: 3 year: 2015 ident: 10.3346/jkms.2025.40.e259_ref20 publication-title: Thromb Res doi: 10.1016/j.thromres.2014.12.025 – volume: 59 start-page: 1 issue: RR-3 year: 2010 ident: 10.3346/jkms.2025.40.e259_ref25 publication-title: MMWR Recomm Rep |
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| SubjectTerms | Adult Aged Colitis, Ulcerative - drug therapy Colitis, Ulcerative - pathology Databases, Factual Female Herpes Zoster - epidemiology Humans Incidence Janus Kinase Inhibitors - adverse effects Janus Kinase Inhibitors - therapeutic use Male Middle Aged Piperidines - adverse effects Piperidines - therapeutic use Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Pyrimidines - adverse effects Pyrimidines - therapeutic use Republic of Korea - epidemiology Risk Factors Severity of Illness Index Thromboembolism - epidemiology Thromboembolism - etiology Tumor Necrosis Factor Inhibitors - adverse effects Tumor Necrosis Factor Inhibitors - therapeutic use Young Adult 의학일반 |
| Title | Long-Term Safety of Tofacitinib for Treatment of Moderate-to-Severe Ulcerative Colitis: Three Years of Korean National Data |
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