A Multicenter Study on Symptomatic Neonatal Herpes Simplex Virus Infection in Korea From 2008 to 2017
Neonatal herpes simplex virus (HSV) infection is rare but can cause severe disease, even death. However, data on neonatal HSV infection is limited in Asia. Thus, this study estimated the incidence of neonatal HSV infections and evaluated the characteristics in hospitalized patients in Korea, where s...
Uložené v:
| Vydané v: | Journal of Korean medical science Ročník 40; číslo 42; s. e282 - 8 |
|---|---|
| Hlavní autori: | , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
Korea (South)
대한의학회
03.11.2025
|
| Predmet: | |
| ISSN: | 1011-8934, 1598-6357, 1598-6357 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Neonatal herpes simplex virus (HSV) infection is rare but can cause severe disease, even death. However, data on neonatal HSV infection is limited in Asia. Thus, this study estimated the incidence of neonatal HSV infections and evaluated the characteristics in hospitalized patients in Korea, where seroprevalence of HSV infection in child-bearing age women is not well known.
This is the first multicenter retrospective study in 12 university hospitals in Korea. Neonates aged ≤ 28 days with confirmed HSV infection were identified from January 2008 to December 2017, and a chart review was performed.
Among 12 medical centers, 16 patients were identified in 6 centers. The estimated incidence rate was 1/7,888 in hospitalized neonates. Eight (50%) patients were males, and the median age at diagnosis was 11 days (range, 4-28 days). Ten (62.5%) patients were HSV-1-positive, and 6 (37.5%) patients were HSV-2-positive. Four (25%) patients had disseminated infection, 11 (68.8%) patients had central nervous system disease, and 1 (6.2%) patient had skin, eye, and/or mouth disease. All the patients received intravenous acyclovir, with a median treatment duration of 19 days (range, 3-68 days). Four (25%) patients received additional oral acyclovir suppressive therapy, with the median treatment duration of 5 months (3-6 months). Four patients (25%) developed seizures (one case with disseminated disease and 3 cases with central nervous system disease), and 2 of them recovered without neurologic complications. Two (12.5%) patients with disseminated disease died within 30 days from the diagnosis, and one of them had a maternal history of previous genital herpetic lesions. Medical records of maternal genital herpes were not available in 10 (62.5%) patients with neonatal HSV infections.
Although uncommon, neonatal HSV infection occurs in Korean babies with a high 30-day mortality of 12.5%. Increased awareness is warranted among Korean pediatricians for the early diagnosis and treatment of neonatal HSV infection. |
|---|---|
| AbstractList | Neonatal herpes simplex virus (HSV) infection is rare but can cause severe disease, even death. However, data on neonatal HSV infection is limited in Asia. Thus, this study estimated the incidence of neonatal HSV infections and evaluated the characteristics in hospitalized patients in Korea, where seroprevalence of HSV infection in child-bearing age women is not well known.BACKGROUNDNeonatal herpes simplex virus (HSV) infection is rare but can cause severe disease, even death. However, data on neonatal HSV infection is limited in Asia. Thus, this study estimated the incidence of neonatal HSV infections and evaluated the characteristics in hospitalized patients in Korea, where seroprevalence of HSV infection in child-bearing age women is not well known.This is the first multicenter retrospective study in 12 university hospitals in Korea. Neonates aged ≤ 28 days with confirmed HSV infection were identified from January 2008 to December 2017, and a chart review was performed.METHODSThis is the first multicenter retrospective study in 12 university hospitals in Korea. Neonates aged ≤ 28 days with confirmed HSV infection were identified from January 2008 to December 2017, and a chart review was performed.Among 12 medical centers, 16 patients were identified in 6 centers. The estimated incidence rate was 1/7,888 in hospitalized neonates. Eight (50%) patients were males, and the median age at diagnosis was 11 days (range, 4-28 days). Ten (62.5%) patients were HSV-1-positive, and 6 (37.5%) patients were HSV-2-positive. Four (25%) patients had disseminated infection, 11 (68.8%) patients had central nervous system disease, and 1 (6.2%) patient had skin, eye, and/or mouth disease. All the patients received intravenous acyclovir, with a median treatment duration of 19 days (range, 3-68 days). Four (25%) patients received additional oral acyclovir suppressive therapy, with the median treatment duration of 5 months (3-6 months). Four patients (25%) developed seizures (one case with disseminated disease and 3 cases with central nervous system disease), and 2 of them recovered without neurologic complications. Two (12.5%) patients with disseminated disease died within 30 days from the diagnosis, and one of them had a maternal history of previous genital herpetic lesions. Medical records of maternal genital herpes were not available in 10 (62.5%) patients with neonatal HSV infections.RESULTSAmong 12 medical centers, 16 patients were identified in 6 centers. The estimated incidence rate was 1/7,888 in hospitalized neonates. Eight (50%) patients were males, and the median age at diagnosis was 11 days (range, 4-28 days). Ten (62.5%) patients were HSV-1-positive, and 6 (37.5%) patients were HSV-2-positive. Four (25%) patients had disseminated infection, 11 (68.8%) patients had central nervous system disease, and 1 (6.2%) patient had skin, eye, and/or mouth disease. All the patients received intravenous acyclovir, with a median treatment duration of 19 days (range, 3-68 days). Four (25%) patients received additional oral acyclovir suppressive therapy, with the median treatment duration of 5 months (3-6 months). Four patients (25%) developed seizures (one case with disseminated disease and 3 cases with central nervous system disease), and 2 of them recovered without neurologic complications. Two (12.5%) patients with disseminated disease died within 30 days from the diagnosis, and one of them had a maternal history of previous genital herpetic lesions. Medical records of maternal genital herpes were not available in 10 (62.5%) patients with neonatal HSV infections.Although uncommon, neonatal HSV infection occurs in Korean babies with a high 30-day mortality of 12.5%. Increased awareness is warranted among Korean pediatricians for the early diagnosis and treatment of neonatal HSV infection.CONCLUSIONAlthough uncommon, neonatal HSV infection occurs in Korean babies with a high 30-day mortality of 12.5%. Increased awareness is warranted among Korean pediatricians for the early diagnosis and treatment of neonatal HSV infection. Neonatal herpes simplex virus (HSV) infection is rare but can cause severe disease, even death. However, data on neonatal HSV infection is limited in Asia. Thus, this study estimated the incidence of neonatal HSV infections and evaluated the characteristics in hospitalized patients in Korea, where seroprevalence of HSV infection in child-bearing age women is not well known. This is the first multicenter retrospective study in 12 university hospitals in Korea. Neonates aged ≤ 28 days with confirmed HSV infection were identified from January 2008 to December 2017, and a chart review was performed. Among 12 medical centers, 16 patients were identified in 6 centers. The estimated incidence rate was 1/7,888 in hospitalized neonates. Eight (50%) patients were males, and the median age at diagnosis was 11 days (range, 4-28 days). Ten (62.5%) patients were HSV-1-positive, and 6 (37.5%) patients were HSV-2-positive. Four (25%) patients had disseminated infection, 11 (68.8%) patients had central nervous system disease, and 1 (6.2%) patient had skin, eye, and/or mouth disease. All the patients received intravenous acyclovir, with a median treatment duration of 19 days (range, 3-68 days). Four (25%) patients received additional oral acyclovir suppressive therapy, with the median treatment duration of 5 months (3-6 months). Four patients (25%) developed seizures (one case with disseminated disease and 3 cases with central nervous system disease), and 2 of them recovered without neurologic complications. Two (12.5%) patients with disseminated disease died within 30 days from the diagnosis, and one of them had a maternal history of previous genital herpetic lesions. Medical records of maternal genital herpes were not available in 10 (62.5%) patients with neonatal HSV infections. Although uncommon, neonatal HSV infection occurs in Korean babies with a high 30-day mortality of 12.5%. Increased awareness is warranted among Korean pediatricians for the early diagnosis and treatment of neonatal HSV infection. Background: Neonatal herpes simplex virus (HSV) infection is rare but can cause severe disease, even death. However, data on neonatal HSV infection is limited in Asia. Thus, this study estimated the incidence of neonatal HSV infections and evaluated the characteristics in hospitalized patients in Korea, where seroprevalence of HSV infection in child-bearing age women is not well known. Methods: This is the first multicenter retrospective study in 12 university hospitals in Korea. Neonates aged ≤ 28 days with confirmed HSV infection were identified from January 2008 to December 2017, and a chart review was performed. Results: Among 12 medical centers, 16 patients were identified in 6 centers. The estimated incidence rate was 1/7,888 in hospitalized neonates. Eight (50%) patients were males, and the median age at diagnosis was 11 days (range, 4–28 days). Ten (62.5%) patients were HSV-1- positive, and 6 (37.5%) patients were HSV-2-positive. Four (25%) patients had disseminated infection, 11 (68.8%) patients had central nervous system disease, and 1 (6.2%) patient had skin, eye, and/or mouth disease. All the patients received intravenous acyclovir, with a median treatment duration of 19 days (range, 3–68 days). Four (25%) patients received additional oral acyclovir suppressive therapy, with the median treatment duration of 5 months (3–6 months). Four patients (25%) developed seizures (one case with disseminated disease and 3 cases with central nervous system disease), and 2 of them recovered without neurologic complications. Two (12.5%) patients with disseminated disease died within 30 days from the diagnosis, and one of them had a maternal history of previous genital herpetic lesions. Medical records of maternal genital herpes were not available in 10 (62.5%) patients with neonatal HSV infections. Conclusion: Although uncommon, neonatal HSV infection occurs in Korean babies with a high 30-day mortality of 12.5%. Increased awareness is warranted among Korean pediatricians for the early diagnosis and treatment of neonatal HSV infection. KCI Citation Count: 0 |
| Author | Lee, Byung-Kook Lee, Hyunju Park, Su Eun Kim, Kyung-Ran Kim, Dongsub Kim, Kyung-Hyo Cho, Eun Young Jo, Dae Sun Kim, Yae-Jean Eun, Byung Wook Han, Seung Beom Cho, Hye-Kyung Park, Ji Young Choi, Joon-sik Kim, Yun-Kyung |
| Author_xml | – sequence: 1 givenname: Dongsub orcidid: 0000-0002-9836-6769 surname: Kim fullname: Kim, Dongsub organization: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Department of Pediatrics, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea – sequence: 2 givenname: Kyung-Ran orcidid: 0000-0003-2557-3000 surname: Kim fullname: Kim, Kyung-Ran organization: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Department of Pediatrics, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Changwon, Korea – sequence: 3 givenname: Joon-sik orcidid: 0000-0002-5587-2960 surname: Choi fullname: Choi, Joon-sik organization: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Department of Pediatrics, Gangnam Severance Hospital, Seoul, Korea – sequence: 4 givenname: Ji Young orcidid: 0000-0002-6777-0494 surname: Park fullname: Park, Ji Young organization: Department of Pediatrics, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea., Department of Pediatrics, Korea University Ansan Hospital, Ansan, Korea – sequence: 5 givenname: Su Eun orcidid: 0000-0001-5860-821X surname: Park fullname: Park, Su Eun organization: Department of Pediatrics, Pusan National University School of Medicine, Yangsan, Korea – sequence: 6 givenname: Byung-Kook orcidid: 0000-0001-9162-3390 surname: Lee fullname: Lee, Byung-Kook organization: Department of Pediatrics, Yonsei University Wonju College of Medicine, Wonju, Korea., Department of Pediatrics, Chungnam National University Sejong Hospital, Sejong, Korea – sequence: 7 givenname: Hyunju orcidid: 0000-0003-0107-0724 surname: Lee fullname: Lee, Hyunju organization: Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea – sequence: 8 givenname: Seung Beom orcidid: 0000-0002-1299-2137 surname: Han fullname: Han, Seung Beom organization: Department of Pediatrics, Bucheon St. Mary’s Hospital, The Catholic University of Korea, Seoul, Korea – sequence: 9 givenname: Eun Young orcidid: 0000-0002-2286-4593 surname: Cho fullname: Cho, Eun Young organization: Department of Pediatrics, Chungnam National University College of Medicine, Daejeon, Korea – sequence: 10 givenname: Hye-Kyung orcidid: 0000-0003-0990-1350 surname: Cho fullname: Cho, Hye-Kyung organization: Department of Pediatrics, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea., Department of Pediatrics, Ewha Womans University College of Medicine, Seoul, Korea – sequence: 11 givenname: Byung Wook orcidid: 0000-0003-3147-9061 surname: Eun fullname: Eun, Byung Wook organization: Department of Pediatrics, Nowon Eulji University Hospital, Eulji University School of Medicine, Seoul, Korea – sequence: 12 givenname: Dae Sun orcidid: 0000-0002-3141-9539 surname: Jo fullname: Jo, Dae Sun organization: Department of Pediatrics, Jeonbuk National University Medical School, Jeonju, Korea – sequence: 13 givenname: Yun-Kyung orcidid: 0000-0003-4396-8671 surname: Kim fullname: Kim, Yun-Kyung organization: Department of Pediatrics, Korea University Ansan Hospital, Ansan, Korea – sequence: 14 givenname: Kyung-Hyo orcidid: 0000-0002-0333-6808 surname: Kim fullname: Kim, Kyung-Hyo organization: Department of Pediatrics, Ewha Womans University College of Medicine, Seoul, Korea – sequence: 15 givenname: Yae-Jean orcidid: 0000-0002-8367-3424 surname: Kim fullname: Kim, Yae-Jean organization: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Samsung Advanced Institute for Health Sciences and Technology, Seoul, Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/41185580$$D View this record in MEDLINE/PubMed https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART003260860$$DAccess content in National Research Foundation of Korea (NRF) |
| BookMark | eNo9kU1P4zAQhi3Eio_u_gAuyEeElK4_E-dYIQoV7CJRdq-W406QaWIHO5HovyehwGH0jjTPzGGeU3TogweEziiZcy7y3y_bNs0ZYXIuyByYYgfohMpSZTmXxeHYE0ozVXJxjE5TeiEjKRk_QseCUiWlIicIFvjP0PTOgu8h4nU_bHY4eLzetV0fWjNO8F8I3vSmwbcQO0h47dqugTf838Uh4ZWvwfZu3HEe34UIBi9jaDEjROE-jEmLn-hHbZoEvz5zhv4tr5-ubrP7h5vV1eI-s0wolqlKbCSracWKSkKuSgr5RlmeF-ONshalZbVQuTS24NKY0tYlSCCV4MwwSQo-Q5f7uz7WemudDsZ95HPQ26gXj08rTUlR8Klm6GIPdzG8DpB63bpkoWmMhzAkzVmuhBA55SN6_okOVQsb3UXXmrjTX38cAboHbAwpRai_EUr05EpPrvTkSguiJ1f8HevyhIY |
| Cites_doi | 10.1093/jpids/pis138 10.1542/peds.2012-3216 10.1002/jmv.29024 10.1542/peds.2018-3233 10.1136/archdischild-2013-303762 10.1542/9781610025225-part03-ch061 10.1053/j.semperi.2007.01.003 10.1001/jama.289.2.203 10.3349/ymj.2012.53.2.401 10.1128/CMR.17.1.1-13.2004 10.1016/S2214-109X(16)30362-X 10.1056/NEJMoa1003509 |
| ContentType | Journal Article |
| Copyright | 2025 The Korean Academy of Medical Sciences. |
| Copyright_xml | – notice: 2025 The Korean Academy of Medical Sciences. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 ACYCR |
| DOI | 10.3346/jkms.2025.40.e282 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Korean Citation Index |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1598-6357 |
| EndPage | 8 |
| ExternalDocumentID | oai_kci_go_kr_ARTI_10773077 41185580 10_3346_jkms_2025_40_e282 |
| Genre | Multicenter Study Journal Article |
| GeographicLocations | Republic of Korea |
| GeographicLocations_xml | – name: Republic of Korea |
| GrantInformation_xml | – fundername: Korean Society of Pediatric Infectious Diseases |
| GroupedDBID | --- 29K 2WC 3O- 5-W 53G 5GY 8JR 8XY AAYXX ADBBV ADRAZ AENEX ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL CITATION CS3 D-I DIK DU5 E3Z EBS EF. EJD F5P FRP GROUPED_DOAJ GX1 HYE KQ8 M48 O5R O5S OK1 OVT PGMZT RNS RPM TR2 W2D XSB CGR CUY CVF ECM EIF NPM 7X8 ACYCR |
| ID | FETCH-LOGICAL-c2482-8b4d52f1b27b5e6891e6d8c3670179f49c2f4865ac735aa9cf9e5e0b432a25073 |
| ISSN | 1011-8934 1598-6357 |
| IngestDate | Wed Nov 05 03:19:19 EST 2025 Tue Nov 04 16:36:32 EST 2025 Sun Nov 09 02:46:08 EST 2025 Wed Nov 05 20:53:21 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 42 |
| Keywords | Neonatal Herpes Simplex Virus Infection Acyclovir Mortality Incidence Korea |
| Language | English |
| License | 2025 The Korean Academy of Medical Sciences. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c2482-8b4d52f1b27b5e6891e6d8c3670179f49c2f4865ac735aa9cf9e5e0b432a25073 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-0990-1350 0000-0002-8367-3424 0000-0002-1299-2137 0000-0002-3141-9539 0000-0002-5587-2960 0000-0002-0333-6808 0000-0001-9162-3390 0000-0003-0107-0724 0000-0001-5860-821X 0000-0003-3147-9061 0000-0003-4396-8671 0000-0002-9836-6769 0000-0002-2286-4593 0000-0003-2557-3000 0000-0002-6777-0494 |
| OpenAccessLink | https://doi.org/10.3346/jkms.2025.40.e282 |
| PMID | 41185580 |
| PQID | 3268444613 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | nrf_kci_oai_kci_go_kr_ARTI_10773077 proquest_miscellaneous_3268444613 pubmed_primary_41185580 crossref_primary_10_3346_jkms_2025_40_e282 |
| PublicationCentury | 2000 |
| PublicationDate | 2025-11-03 |
| PublicationDateYYYYMMDD | 2025-11-03 |
| PublicationDate_xml | – month: 11 year: 2025 text: 2025-11-03 day: 03 |
| PublicationDecade | 2020 |
| PublicationPlace | Korea (South) |
| PublicationPlace_xml | – name: Korea (South) |
| PublicationTitle | Journal of Korean medical science |
| PublicationTitleAlternate | J Korean Med Sci |
| PublicationYear | 2025 |
| Publisher | 대한의학회 |
| Publisher_xml | – name: 대한의학회 |
| References | De Rose (10.3346/jkms.2025.40.e282_ref7) 2023; 95 Kimberlin (10.3346/jkms.2025.40.e282_ref10) 2013; 2 Kim (10.3346/jkms.2025.40.e282_ref14) 2012; 53 Kimberlin (10.3346/jkms.2025.40.e282_ref1) 2021 Pinninti (10.3346/jkms.2025.40.e282_ref11) 2014; 99 Hollier (10.3346/jkms.2025.40.e282_ref13) 2008 Looker (10.3346/jkms.2025.40.e282_ref4) 2017; 5 Mahant (10.3346/jkms.2025.40.e282_ref6) 2019; 143 Kimberlin (10.3346/jkms.2025.40.e282_ref12) 2004; 17 Brown (10.3346/jkms.2025.40.e282_ref8) 2003; 289 Sonoda (10.3346/jkms.2025.40.e282_ref5) 2020; 30 Kimberlin (10.3346/jkms.2025.40.e282_ref2) 2007; 31 Kimberlin (10.3346/jkms.2025.40.e282_ref3) 2013; 131 Kimberlin (10.3346/jkms.2025.40.e282_ref9) 2011; 365 |
| References_xml | – volume: 2 start-page: 179 issue: 2 year: 2013 ident: 10.3346/jkms.2025.40.e282_ref10 publication-title: J Pediatric Infect Dis Soc doi: 10.1093/jpids/pis138 – volume: 131 start-page: e635 issue: 2 year: 2013 ident: 10.3346/jkms.2025.40.e282_ref3 publication-title: Pediatrics doi: 10.1542/peds.2012-3216 – volume: 95 start-page: e29024 issue: 8 year: 2023 ident: 10.3346/jkms.2025.40.e282_ref7 publication-title: J Med Virol doi: 10.1002/jmv.29024 – volume: 143 start-page: e20183233 issue: 4 year: 2019 ident: 10.3346/jkms.2025.40.e282_ref6 publication-title: Pediatrics doi: 10.1542/peds.2018-3233 – volume: 99 start-page: F240 issue: 3 year: 2014 ident: 10.3346/jkms.2025.40.e282_ref11 publication-title: Arch Dis Child Fetal Neonatal Ed doi: 10.1136/archdischild-2013-303762 – start-page: 407 volume-title: Red Book year: 2021 ident: 10.3346/jkms.2025.40.e282_ref1 doi: 10.1542/9781610025225-part03-ch061 – volume: 31 start-page: 19 issue: 1 year: 2007 ident: 10.3346/jkms.2025.40.e282_ref2 publication-title: Semin Perinatol doi: 10.1053/j.semperi.2007.01.003 – volume: 289 start-page: 203 issue: 2 year: 2003 ident: 10.3346/jkms.2025.40.e282_ref8 publication-title: JAMA doi: 10.1001/jama.289.2.203 – volume: 53 start-page: 401 issue: 2 year: 2012 ident: 10.3346/jkms.2025.40.e282_ref14 publication-title: Yonsei Med J doi: 10.3349/ymj.2012.53.2.401 – volume: 17 start-page: 1 issue: 1 year: 2004 ident: 10.3346/jkms.2025.40.e282_ref12 publication-title: Clin Microbiol Rev doi: 10.1128/CMR.17.1.1-13.2004 – volume: 30 start-page: S43 issue: 1 year: 2020 ident: 10.3346/jkms.2025.40.e282_ref5 publication-title: Japan Soc Obstet, Gynecol Neonatal Hematol – volume: 5 start-page: e300 issue: 3 year: 2017 ident: 10.3346/jkms.2025.40.e282_ref4 publication-title: Lancet Glob Health doi: 10.1016/S2214-109X(16)30362-X – start-page: CD004946 issue: 1 year: 2008 ident: 10.3346/jkms.2025.40.e282_ref13 publication-title: Cochrane Database Syst Rev – volume: 365 start-page: 1284 issue: 14 year: 2011 ident: 10.3346/jkms.2025.40.e282_ref9 publication-title: N Engl J Med doi: 10.1056/NEJMoa1003509 |
| SSID | ssj0025523 |
| Score | 2.4067822 |
| Snippet | Neonatal herpes simplex virus (HSV) infection is rare but can cause severe disease, even death. However, data on neonatal HSV infection is limited in Asia.... Background: Neonatal herpes simplex virus (HSV) infection is rare but can cause severe disease, even death. However, data on neonatal HSV infection is limited... |
| SourceID | nrf proquest pubmed crossref |
| SourceType | Open Website Aggregation Database Index Database |
| StartPage | e282 |
| SubjectTerms | Acyclovir - therapeutic use Antiviral Agents - therapeutic use Female Herpes Simplex - diagnosis Herpes Simplex - drug therapy Herpes Simplex - epidemiology Herpes Simplex - mortality Herpes Simplex - pathology Herpesvirus 1, Human - isolation & purification Herpesvirus 2, Human - isolation & purification Humans Incidence Infant, Newborn Male Pregnancy Pregnancy Complications, Infectious - diagnosis Pregnancy Complications, Infectious - drug therapy Pregnancy Complications, Infectious - epidemiology Republic of Korea - epidemiology Retrospective Studies 의학일반 |
| Title | A Multicenter Study on Symptomatic Neonatal Herpes Simplex Virus Infection in Korea From 2008 to 2017 |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/41185580 https://www.proquest.com/docview/3268444613 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART003260860 |
| Volume | 40 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Journal of Korean Medical Science, 2025, 40(42), , pp.1-8 |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1598-6357 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0025523 issn: 1011-8934 databaseCode: DOA dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lj9MwELbaBa32gnhTHisjOFFlSRM7do7VAgJWVCu6oL1ZSeosodSp0nbV_gb-NDN20paiSnDgkkbOw9XMp8mMPfMNIS8lknyxNPdkFGmPJTLykkiMPJ35SZryjEd5bptNiMFAXl7G563Wz6YW5vqHMEYul_H0v6oaxkDZWDr7D-pevxQG4ByUDkdQOxz_SvH9ri2qxaxLXdk8wRXuCAxXk-m8dAStA41r5pZWuJrqWXdYIEfwsvu1qBYzMBkuP8vmQJ6V4FWCe1tOkHxQoqsKH3Oxx6e1dxu3Yd9UW26gU3duflOaq9ki3Rk9W4HZ8T5vwHr6rSzc-n5pvGGxrig6r7O7PxZda6q21y0Cbgv4nC3Tta2NpYd0eNvG2HE31aBzvFu1adWB61K0a_PD0JIdfx9PkH094CfMP9m9FzQ0nVh9MwioOHfNo3aItptLbXIjEPDfmvi8jt45hOxuWxxnfP3HfEfksHnDbz5O21T5_vDFujEXt8mtWle073Bzh7S0uUsOP9UZFveI7tMt-FALH1oaugUf2sCHOvjQGj7Uwoeu4UMLQy0gKMKHInzovKQIn_vky7u3F6fvvboVh5cFDGIwmbIRD_JeGoiU60jGPR2NZIbsf2DRcxZnQc5kxJNMhDxJ4iyPNdd-ysIgASdbhA_IgSmNfkRo3Evznh_JJILQH-JtqUdpLLAtQB7mOvQ75FUjPDV1jCsKIlUUukKhKxS6Yr5CoXfICxCvGmeFQp50_L0q1bhSEA1-gMcEfMCE6JDnjfgVWE_cEkuMLhczFSLZEWPg03bIQ6eX9aSNNh_vvfKEHG2Q_ZQczKuFfkZuZtfzYlYdk7a4lMcWRL8AVK2Qtw |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+Multicenter+Study+on+Symptomatic+Neonatal+Herpes+Simplex+Virus+Infection+in+Korea+From+2008+to+2017&rft.jtitle=Journal+of+Korean+medical+science&rft.au=Kim%2C+Dongsub&rft.au=Kim%2C+Kyung-Ran&rft.au=Choi%2C+Joon-Sik&rft.au=Park%2C+Ji+Young&rft.date=2025-11-03&rft.eissn=1598-6357&rft.volume=40&rft.issue=42&rft.spage=e282&rft_id=info:doi/10.3346%2Fjkms.2025.40.e282&rft_id=info%3Apmid%2F41185580&rft.externalDocID=41185580 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1011-8934&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1011-8934&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1011-8934&client=summon |