Response Surface Modeling and Multi-objective Genetic Algorithm Optimization of Polyphenol/terpineol Yield from Luffa cylindrica Oil

Using the Response surface methodology (RSM) and multi-objective genetic algorithm (MOGA) techniques, this study investigated the optimal extraction conditions of polyphenol and terpineol from luffa cylindrica oil. The antioxidant activity was examined using the stable free radical: 2,2-diphenyl-1-p...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences, India. Section B: Biological sciences Vol. 94; no. 5; pp. 1041 - 1049
Main Authors: Nwosu-Obieogu, Kenechi, Dzarma, Goziya W., Linus, Chiemenem, Nwosu, Ozioma, Udemgba, Chinonso
Format: Journal Article
Language:English
Published: New Delhi Springer India 01.11.2024
Subjects:
2,2-diphenyl-1-picrylhydrazyl
algorithms
antioxidant activity
Behavioral Sciences
Biomedical and Life Sciences
Fourier transform infrared spectroscopy
free radicals
gas chromatography-mass spectrometry
India
Life Sciences
Luffa aegyptiaca
Nucleic Acid Chemistry
oils
Plant Biochemistry
polyphenols
Research Article
response surface methodology
temperature
terpineol
India
Polyphenol
oil
Terpineol
Optimization
ISSN:0369-8211, 2250-1746
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Summary:Using the Response surface methodology (RSM) and multi-objective genetic algorithm (MOGA) techniques, this study investigated the optimal extraction conditions of polyphenol and terpineol from luffa cylindrica oil. The antioxidant activity was examined using the stable free radical: 2,2-diphenyl-1-picrylhydrazyl (DPPH). Under optimal conditions, luffa cylindrica oil was extracted for terpineol/polyphenol yield analysis. The process was optimized using a Box–Behnken design with a genetic algorithm (GA) solver and response surface technique. The process variables are time and temperature, with terpineol and polyphenol yield being the responses. The ability of the models built from the process variables and the response was assessed using the coefficient of determination (for terpineol: R 2 —0.9999, Adj R 2 —0.9998, Pred R 2 —0.9991; for polyphenol: R 2 —0.9880, Adj R 2 —0.9795, Pred R 2 —0.9149). The results indicated a good agreement between the observed and predicted data. RSM achieved an optimum extraction of 7.71907 mg/g terpineol and 2.36748 mg/g polyphenol at 62.71 °C and 4.87 h. In contrast, MOGA predicted extraction optimal conditions of 7.264 mg/g terpineol and 2.327 mg/g polyphenol was obtained at 60.231 °C and 4 h. While the gas chromatography-mass spectrometry validated the percentages of 29.1 and 16.8 for terpineol and polyphenol, respectively, the Fourier transform infrared spectroscopy showed that terpineol and polyphenol were present at the peak of 1461.1 and 3008.0 cm −1 . Terpineol and polyphenol also showed significant scavenging of DPPH radicals with (32.5 and 34.5)% at 100 μg/ml. This study's novelty dwells on optimizing the extraction process of terpineol/polyphenol using RSM and GA techniques.
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ISSN:0369-8211
2250-1746
DOI:10.1007/s40011-024-01635-y