P39: Left Ventricular Structure and Function in Relation to Peripheral and Central Blood Pressure in A General Population
Background Central blood pressure (BP) is a predictor of target organ damage. No previous study addressed the question to what extent central compared with peripheral is related to left ventricular (LV) structure and function in a general population. Methods In 577 Flemish recruited from the general...
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| Published in: | Artery research Vol. 20; no. 1; p. 66 |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Dordrecht
Springer Netherlands
01.12.2017
Springer Nature B.V BMC |
| Subjects: | |
| ISSN: | 1872-9312, 1876-4401, 1876-4401 |
| Online Access: | Get full text |
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| Summary: | Background
Central blood pressure (BP) is a predictor of target organ damage. No previous study addressed the question to what extent central compared with peripheral is related to left ventricular (LV) structure and function in a general population.
Methods
In 577 Flemish recruited from the general population (47.8% women; mean age 50.5 years), we assessed the multivariable-adjusted associations of echocardiographic LV structure and systolic and diastolic LV function (Vivid7 Pro device; EchoPac software, version 4.0.4; GE Vingmed, Horten, Norway) with peripheral and central pressure, as recorded by radial applanation tonometry (SphygmoCor software, version 9.0). Association sizes were expressed per 15/10 mmHg increment in peripheral or central systolic/diastolic BP.
Results
Peripheral compared with central systolic BP was 10.2mm Hg higher (
P
< 0.0001), whereas diastolic BP was similar peripherally and centrally (
P
= 0.50). Associations were closer (
P
≤ 0.020) with central than peripheral systolic BP for LV mass (+0.59 g/m
2
) and left atrial volume (+0.29 ml/m
2
) indexed to body surface area, peak A transmitral flow (+0.12 cm/s), peak e’ mitral annular movement (−0.18 cm/s) and the E/A ratio (−0.017). Associations were closer (
P
≤ 0.038) with central than peripheral diastolic BP for left atrial volume index (+0.289 ml/m
2
), e’ (−0.123 cm/s) and E/e’ (+0.094). Ejection fraction and global longitudinal strain were similarly associated with central and peripheral systolic (
P
≥ 0.62) and diastolic (
P
≥ 0.18) BP.
Conclusions
In asymptomatic people recruited from the general population, LV mass and atrial volume indexes and selected haemodynamic measurements reflecting diastolic LV function are slightly but significantly closer associated with central than peripheral BP. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 |
| ISSN: | 1872-9312 1876-4401 1876-4401 |
| DOI: | 10.1016/j.artres.2017.10.069 |