Protection of the human aortic valve interstitial cells against radiation-induced remodeling by repression of the TRPM4 channel

Radiation-induced aortic valve deleterious remodeling may occur years after radiotherapy. The transient receptor potential melastatin 4 (TRPM4) cation channel participates in aortic valve radiation-induced remodeling in mice in vivo. Valvular interstitial cells (VICs) are involved in valve leaflet t...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology Jg. 329; H. 5; S. C1487
Hauptverfasser:	Aize, Margaux, Brard, Laura, Kerevel, Corentin, Boilève, Arthur, Mpweme Bangando, Harlyne, Touihar, Maysan, Roussel, Benoit D, Lebrun, Alexandre, Saplacan, Vladimir, Manrique, Alain, Simard, Christophe, Guinamard, Romain
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.11.2025
Schlagworte:	Aged Animals Aortic Valve - metabolism Aortic Valve - pathology Aortic Valve - radiation effects Aortic Valve Stenosis - metabolism Aortic Valve Stenosis - pathology Cell Proliferation - radiation effects Cell Survival - radiation effects Cells, Cultured Cellular Senescence - radiation effects Core Binding Factor Alpha 1 Subunit - genetics Core Binding Factor Alpha 1 Subunit - metabolism Female Humans Male Osteogenesis - radiation effects Phenanthrenes - pharmacology TRPM Cation Channels - antagonists & inhibitors TRPM Cation Channels - genetics TRPM Cation Channels - metabolism senescence radiotherapy aortic valve aortic stenosis TRP channels
ISSN:	1522-1563, 1522-1563
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