Medication-Related Osteonecrosis of the Jaw: a Brief Review, Treatment and Practical Guidelines for Dentists

Osteonecrosis of the jaws is a complication after treatment with antiresorptive drugs. Bisphosphonates (BPs) are widely used to treat conditions with bone metastases of malignant tumors such as multiple myeloma, breast cancer, prostatic cancer, as well as hypercalcemia of malignancy, osteoporosis, P...

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Bibliographic Details
Published in:Journal of Interdisciplinary Medicine Vol. 2; no. 2; pp. 117 - 121
Main Authors: Albu-Stan, Ioana-Aurița, Albu, Daniel-Emil, Cerghizan, Diana, Eremie, Lia Yero, Jánosi, Kinga, Baloș, Monica, Copotoiu, Constantin
Format: Journal Article
Language:English
Published: Târgu Mureș Sciendo 01.06.2017
De Gruyter Brill Sp. z o.o., Paradigm Publishing Services
Subjects:
antiresorptive drugs
bisphosphonates
Disease
Necrosis
osteonecrosis
Osteoporosis
quality of life
surgery
ISSN:2501-8132, 2501-5974, 2501-8132
Online Access:Get full text
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Summary:Osteonecrosis of the jaws is a complication after treatment with antiresorptive drugs. Bisphosphonates (BPs) are widely used to treat conditions with bone metastases of malignant tumors such as multiple myeloma, breast cancer, prostatic cancer, as well as hypercalcemia of malignancy, osteoporosis, Paget’s disease, and osteogenesis imperfecta. Denosumab is an antiresorptive agent that is used for the treatment of osteoporosis or metastatic bone diseases. These antiresorptive agents improve the quality of life of patients by increasing strength and bone mineral density, and reducing the risk of bone fractures. More than a decade had passed since the first publication of this pathology, and the occurrence of the disease, its pathophysiology, and proper treatment methods are still not fully elucidated. Prevention is critical in medication-related osteonecrosis of the jaw, because the treatment is difficult, and there are no universally accepted treatment protocols. There is an accepted approach of palliation of symptoms and controlling the associated infections. Treatment may follow one of three procedures: conservative management of pain, conservative or extensive (segmental) surgery, depending on the disease stage.
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ISSN:2501-8132
2501-5974
2501-8132
DOI:10.1515/jim-2017-0046