Comparison of Magnetic Resonance Imaging Features Between Programmed Cell Death 1/Programmed Cell Death Ligand 1 Inhibitor-Induced Hypopituitarism and Idiopathic Hypopituitarism in Japanese Subjects

Objective Immune checkpoint inhibitor-associated hypopituitarism (ICI-HP) is a rare immune-related adverse event (irAE) of ICIs. This study aimed to identify characteristic pituitary findings on magnetic resonance imaging (MRI) in ICI-HP. Methods This study is a single-center, retrospective, observa...

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Vydáno v:Curēus (Palo Alto, CA) Ročník 16; číslo 10; s. e71699
Hlavní autoři: Iwamoto, Yuichiro, Kimura, Tomohiko, Dan, Kazunori, Iwamoto, Hideyuki, Sanada, Junpei, Fushimi, Yoshiro, Katakura, Yukino, Shimoda, Masashi, Nakanishi, Shuhei, Mune, Tomoatsu, Kaku, Kohei, Kaneto, Hideaki
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Springer Nature B.V 17.10.2024
Cureus
Témata:
Approximation
Blood pressure
Body mass index
Cancer
Cell death
Chi-square test
Endocrine disorders
Endocrinology/Diabetes/Metabolism
Growth hormones
Immune checkpoint inhibitors
Internal Medicine
Kruskal-Wallis test
Magnetic resonance imaging
Morphology
Oncology
Patients
Pituitary gland
Steroids
Thyroid gland
Tumors
United States > US
magnetic resonance imaging (mri)
hypopituitarism
immune-related adverse events (irae)
idiopathic hypopituitarism
immune checkpoint inhibitors (icis)
ISSN:2168-8184, 2168-8184
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Shrnutí:Objective Immune checkpoint inhibitor-associated hypopituitarism (ICI-HP) is a rare immune-related adverse event (irAE) of ICIs. This study aimed to identify characteristic pituitary findings on magnetic resonance imaging (MRI) in ICI-HP. Methods This study is a single-center, retrospective, observational study. Among 95 patients admitted to our hospital for examination of hypopituitarism between January 2010 and December 2022, 26 patients with normal pituitary function (NPF), 13 patients with ICI-HP, and 13 patients with idiopathic hypopituitarism (IHP) were included and analyzed. Results For participants with ICI-HP, the time from ICI administration to ICI-HP diagnosis was 125 (56-212) days. Compared to the NPF, participants in the ICI-HP and IHP were significantly older (p<0.01) - the highest number of patients presented with isolated adrenocorticotropic hormone deficiency in both ICI-HP and IHP. Pituitary volume was not significantly different among the three groups (p=0.68). The width of the pituitary stalk was 1.8 (1.5-2.0) mm in NPF and 1.8 (1.7-2.2) mm in IHP, whereas it was 2.4 (2.4-2.7) mm in ICI-HP and was significantly larger compared to the other groups (p<0.01). Conclusion This study identified no pituitary enlargement in ICI-HP compared to NPF or IHP. However, the pituitary stalk was significantly thickened in ICI-HP compared to the other groups. Pituitary stalk enlargement may be a characteristic MRI finding of ICI-HP.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.71699