The Effect of Thyroid Function on GDF15 Levels

Growth differentiation factor 15 (GDF15) is a stress-response cytokine, which exerts different actions in physiological and pathological conditions. Thyroid disorders are common in the general population and their role on GDF15 levels has not been sufficiently addressed. Serum levels of GDF-15 and t...

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Vydané v:	International journal of molecular sciences Ročník 26; číslo 22; s. 11073
Hlavní autori:	Profili, Nicia I., Fiorillo, Edoardo, Orrù, Valeria, Cucca, Francesco, Delitala, Alessandro P.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland MDPI AG 16.11.2025
Predmet:	Acute coronary syndromes Adult Aged Antibodies Apixaban Apoptosis Atherosclerosis Autoantibodies - blood Cardiac arrhythmia Cardiovascular disease Cardiovascular system Cytokines Diabetes Female Females Growth Differentiation Factor 15 - blood Heart attacks Heart failure Humans Hypertension Hyperthyroidism Hypothyroidism Iodide Peroxidase - immunology Lipids Male Metabolism Middle Aged Mortality Physiological aspects Thyroid diseases Thyroid Diseases - blood Thyroid gland Thyroid Gland - metabolism Thyroid Gland - physiology Thyrotropin Thyrotropin - blood Thyroxine Thyroxine - blood Type 2 diabetes Valsartan Viral antibodies Italy TSH cardiovascular disease thyrotropin thyroid hormone GDF-15
ISSN:	1422-0067, 1661-6596, 1422-0067
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Shrnutí:	Growth differentiation factor 15 (GDF15) is a stress-response cytokine, which exerts different actions in physiological and pathological conditions. Thyroid disorders are common in the general population and their role on GDF15 levels has not been sufficiently addressed. Serum levels of GDF-15 and thyroid function were assessed in a large sample from the SardiNIA cohort (n = 4413). We further collected antibodies against thyroperoxidase and anti-thyroglobulin in all participants. Thyroid function correlated with GDF15. Specifically, after adjusting for covariates, thyrotropin had a positive association with GDF15, while free thyroxine was negatively correlated. We also found that subjects with circulating antibodies against thyroperoxidase had lower GDF15 levels. The reduced level of the thyroid hormone can cause a decreased metabolic activity and higher cell stress response, which, in turn, increases the production of GDF-15 as a defense mechanism. The association between antibodies against thyroperoxidase and GDF15 deserves additional study to elucidate the pathophysiologic relationship.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms262211073