Increased Suppressor Activity of Ex Vivo Transformed Regulatory T Cells in Comparison with Unstimulated Cells of the Same Donor

— Regulatory T cells CD4 + CD25 + FoxP3 + СD127 low (Tregs) play a key role in the maintenance of tolerance to autoantigens, inhibit the function of effector T and B lymphocytes, and provide a balance between effector and regulatory arms of immunity. Patients with autoimmune diseases are characteriz...

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Bibliographic Details
Published in:	Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Vol. 16; no. 3; pp. 225 - 237
Main Authors:	Blinova, V. G., Gladilina, Y. A., Eliseeva, D. D., Lobaeva, T. A., Zhdanov, D. D.
Format:	Journal Article
Language:	English
Published:	Moscow Pleiades Publishing 01.09.2022 Springer Nature B.V
Subjects:	Adoptive immunotherapy Autoantigens Autografts Autoimmune diseases Bioorganic Chemistry CD25 antigen CD4 antigen Chemistry Chemistry and Materials Science Cyclin B1 Demethylation Foxp3 protein Immune system Immunological tolerance Immunoregulation Immunotherapy Lymphocytes Lymphocytes B Lymphocytes T Medicinal Chemistry Peripheral blood Phenotypes Transplantation Tumor necrosis factor-α γ-Interferon regulatory T cells cell markers suppression activity promoter methylation FoxP3 ex vivo transformation
ISSN:	1990-7508, 1990-7516
Online Access:	Get full text
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