Reduction in hepatic endothelin-1 clearance in cirrhosis

Circulating endothelin-1 (ET-1) levels are increased in cirrhosis. The liver is an important site for circulating ET-1 clearance through the ET(B) receptor. We evaluated ET-1 kinetics in cirrhosis to determine if a reduced liver clearance contributes to this process. Cirrhosis was induced by carbon...

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Vydané v:	Clinical science (1979) Ročník 105; číslo 2; s. 227
Hlavní autori:	Tran Duc, Anh Thu, Schwab, Andreas J, Simard, André, Villeneuve, Louis, Dupuis, Jocelyn
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.08.2003
Predmet:	Animals Blood Pressure Carbon Tetrachloride Endothelin-1 - blood Endothelin-1 - metabolism Liver - metabolism Liver Cirrhosis, Experimental - blood Liver Cirrhosis, Experimental - metabolism Liver Cirrhosis, Experimental - pathology Male Portal Vein - physiopathology Rats Rats, Sprague-Dawley Receptor, Endothelin B Receptors, Endothelin - metabolism
ISSN:	0143-5221
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