Partial bilateral mesencephalic lesions affect D1 but not D2 binding in both the striatum and cortex

The substantia nigra pars compacta (SNc) and the ventral tegmental area (VTA) are the two major mesencephalic dopaminergic systems. Mesencephalic dopamine denervation is followed by long-term modifications in striatum and cortex that preserve dopamine functions. Here, we have studied the impact of i...

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Vydané v:Neurochemistry international Ročník 45; číslo 7; s. 995 - 1004
Hlavní autori: Pioli, Elsa, Sohr, Reinhard, Meissner, Wassilios, Barthe, Nicole, Gross, Christian E., Bezard, Erwan, Bioulac, Bernard H.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Oxford Elsevier 01.12.2004
Predmet:
Animals
Biological and medical sciences
Cerebral Cortex - metabolism
Corpus Striatum - metabolism
Fundamental and applied biological sciences. Psychology
Mesencephalon - metabolism
Protein Binding - physiology
Rats
Rats, Wistar
Receptors, Dopamine D1 - metabolism
Receptors, Dopamine D2 - metabolism
Vertebrates: nervous system and sense organs
Dopamine
Locus niger
Central nervous system
Neurotransmitter
Midbrain
Basal ganglion
Corpus striatum
Lesion
Substantia nigra pars compacta
Catecholamine
Ventral tegmental area
Encephalon
ISSN:0197-0186
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Shrnutí:The substantia nigra pars compacta (SNc) and the ventral tegmental area (VTA) are the two major mesencephalic dopaminergic systems. Mesencephalic dopamine denervation is followed by long-term modifications in striatum and cortex that preserve dopamine functions. Here, we have studied the impact of isolated bilateral 6-hydroxydopamine lesioning of the SNc or the VTA on D(1) and D(2) dopamine receptor binding in striatal and cortical areas of rat. Neither SNc nor VTA bilateral partial lesioning changed D(2) binding at the striatal or cortical level. Intriguingly, only VTA lesioning increased D(1) binding in the cortex, whereas both bilateral partial lesioning of the SNc or the VTA increased striatal D(1) binding. This suggests that increased cortical D(1) binding could be an indicator of VTA lesioning. Further behavioural experiments may explain the pathophysiological meaning of increased cortical D(1) binding, and determine whether this observation is involved in compensatory mechanisms.
Bibliografia:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0197-0186
DOI:10.1016/j.neuint.2004.06.003