Refining Western Dementia-Risk Paradigms: Evidence From a Decade of the Korean Longitudinal Study on Cognitive Aging and Dementia

As the most rapidly aging nation, Korea offers a unique lens into the future of dementia, one of the most pressing global health challenges of the 21st century. The Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD), launched amid the country's rapid demographic transition, exe...

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Published in:Journal of Korean medical science Vol. 40; no. 45; pp. e326 - 19
Main Authors: Han, Ji Won, Oh, Dae Jong, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung-Ho, Youn, Jong Chul, Lee, Dong Young, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Jhoo, Jin Hyeong, Kim, Ki Woong
Format: Journal Article
Language:English
Published: Korea (South) 대한의학회 24.11.2025
Subjects:
Aged
Cognitive Aging
Dementia - diagnosis
Dementia - epidemiology
Dementia - pathology
Dementia - prevention & control
Humans
Longitudinal Studies
Republic of Korea - epidemiology
Risk Factors
의학일반
Republic of Korea
Cognitive Dysfunction
Epidemiology
Longitudinal Studies
Risk Factors
Dementia
Korea
ISSN:1011-8934, 1598-6357, 1598-6357
Online Access:Get full text
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Summary:As the most rapidly aging nation, Korea offers a unique lens into the future of dementia, one of the most pressing global health challenges of the 21st century. The Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD), launched amid the country's rapid demographic transition, exemplifies how population-specific research can guide national policy and challenge universal assumptions in dementia science. More than a cohort study, KLOSCAD provides a methodological blueprint for identifying culturally relevant risk factors, testing the applicability of Western models, and shaping prevention strategies for local contexts. Its evolution from a national study to a globally recognized platform reflects the value of sustained governmental support, strategic design, and international collaboration. As the dementia epidemic's center shifts to Asia, the KLOSCAD experience underscores that diversity is not a confounder but a scientific opportunity, critical for building both universal and context-sensitive approaches to understanding and preventing dementia worldwide.
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ISSN:1011-8934
1598-6357
1598-6357
DOI:10.3346/jkms.2025.40.e326