Laboratory evaluation and transfusion support of patients with autoimmune hemolytic anemia
Although some autoantibodies do not cause hemolysis and their workup is performed routinely, others might lead to life-threatening hemolysis. In the latter situation, the pathologist often is involved in the urgent decision to transfuse before completion of the evaluation. However, every effort must...
Uloženo v:
| Vydáno v: | American journal of clinical pathology Ročník 125 Suppl; s. S71 |
|---|---|
| Hlavní autoři: | , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
England
01.06.2006
|
| Témata: | |
| ISSN: | 0002-9173 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Although some autoantibodies do not cause hemolysis and their workup is performed routinely, others might lead to life-threatening hemolysis. In the latter situation, the pathologist often is involved in the urgent decision to transfuse before completion of the evaluation. However, every effort must be made to exclude the presence of concurrent alloantibodies. This identification of RBC autoantibodies is less common than alloantibody identification, and the evaluation often requires techniques and expertise available only in specialized laboratories. Unlike emergency release of units for trauma victims, an autoantibody by definition will react with all units in the inventory; thus, all crossmatches are expected to be incompatible. To avoid additional untoward consequences of transfusion, there has to be close communication between the consulting pathologist and the clinician, including close monitoring of the patient during and after transfusion. This review is intended to serve as a guide to general pathologists in the appropriate evaluation and interpretation of laboratory tests in the diagnosis and management of autoimmune hemolytic anemia. |
|---|---|
| AbstractList | Although some autoantibodies do not cause hemolysis and their workup is performed routinely, others might lead to life-threatening hemolysis. In the latter situation, the pathologist often is involved in the urgent decision to transfuse before completion of the evaluation. However, every effort must be made to exclude the presence of concurrent alloantibodies. This identification of RBC autoantibodies is less common than alloantibody identification, and the evaluation often requires techniques and expertise available only in specialized laboratories. Unlike emergency release of units for trauma victims, an autoantibody by definition will react with all units in the inventory; thus, all crossmatches are expected to be incompatible. To avoid additional untoward consequences of transfusion, there has to be close communication between the consulting pathologist and the clinician, including close monitoring of the patient during and after transfusion. This review is intended to serve as a guide to general pathologists in the appropriate evaluation and interpretation of laboratory tests in the diagnosis and management of autoimmune hemolytic anemia.Although some autoantibodies do not cause hemolysis and their workup is performed routinely, others might lead to life-threatening hemolysis. In the latter situation, the pathologist often is involved in the urgent decision to transfuse before completion of the evaluation. However, every effort must be made to exclude the presence of concurrent alloantibodies. This identification of RBC autoantibodies is less common than alloantibody identification, and the evaluation often requires techniques and expertise available only in specialized laboratories. Unlike emergency release of units for trauma victims, an autoantibody by definition will react with all units in the inventory; thus, all crossmatches are expected to be incompatible. To avoid additional untoward consequences of transfusion, there has to be close communication between the consulting pathologist and the clinician, including close monitoring of the patient during and after transfusion. This review is intended to serve as a guide to general pathologists in the appropriate evaluation and interpretation of laboratory tests in the diagnosis and management of autoimmune hemolytic anemia. Although some autoantibodies do not cause hemolysis and their workup is performed routinely, others might lead to life-threatening hemolysis. In the latter situation, the pathologist often is involved in the urgent decision to transfuse before completion of the evaluation. However, every effort must be made to exclude the presence of concurrent alloantibodies. This identification of RBC autoantibodies is less common than alloantibody identification, and the evaluation often requires techniques and expertise available only in specialized laboratories. Unlike emergency release of units for trauma victims, an autoantibody by definition will react with all units in the inventory; thus, all crossmatches are expected to be incompatible. To avoid additional untoward consequences of transfusion, there has to be close communication between the consulting pathologist and the clinician, including close monitoring of the patient during and after transfusion. This review is intended to serve as a guide to general pathologists in the appropriate evaluation and interpretation of laboratory tests in the diagnosis and management of autoimmune hemolytic anemia. |
| Author | Marques, Marisa B Reardon, John E |
| Author_xml | – sequence: 1 givenname: John E surname: Reardon fullname: Reardon, John E organization: Department of Pathology, University of Alabama at Birmingham, 35249-7331, USA – sequence: 2 givenname: Marisa B surname: Marques fullname: Marques, Marisa B |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16830958$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1kEFLwzAYhnOYuE29e5KcvFWTNm2S4zZ0igUVFMFLSdKvLNI2tUmU_XsrztPHC8_z8vIt0ax3PSB0TskVzYi8Xq2fyDpn2-eSszJ7eJuhBSEkTSTl2Rwtvf8ghKaCsGM0p4WYlFws0HuptBtVcOMew5dqowrW9Vj1NQ6j6n0T_W_2cRjcGLBr8DAR0AePv23YYRWDs10Xe8A76Fy7D9ZMNnRWnaKjRrUezg73BL3e3rxs7pLycXu_WZWJoUUeEmlACyNILRlvmIEs11IoTpnhhZHS0AxknQlZpBR4rYXQjWDcyJQzoWtQ6Qm6_OsdRvcZwYeqs95A204zXPRVIYp0MvgEXhzAqDuoq2G0nRr31f830h_QmGST |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1309/ABP0B54GQL74L3KW |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine Biology |
| ExternalDocumentID | 16830958 |
| Genre | Journal Article Review |
| GroupedDBID | --- .55 .GJ 0R~ 1CY 1KJ 1TH 23M 2WC 3O- 3V. 4.4 48X 53G 5GY 5RE 5WD 6J9 7RV 7X7 88E 8FE 8FH 8FI 8FJ AABZA AACZT AAIMJ AAJQQ AAMDB AAMVS AAPGJ AAPQZ AAPXW AAQOH AAQQT AARHZ AAUAY AAUQX AAVAP AAWDT AAWTL ABCQX ABDFA ABDPE ABEJV ABEUO ABGNP ABIXL ABJNI ABLJU ABMNT ABNHQ ABPPZ ABPQP ABPTD ABQNK ABSAR ABSMQ ABUWG ABVGC ABWST ABXVV ACBNA ACFRR ACGFO ACGFS ACPRK ACUFI ACUTJ ACVCV ACYHN ACZBC ADBBV ADFRT ADGZP ADHKW ADIPN ADMTO ADQBN ADRTK ADVEK AELWJ AEMDU AENEX AENZO AEPUE AETBJ AEWNT AFFNX AFFQV AFFZL AFGWE AFIYH AFKRA AFOFC AFXEN AFYAG AGINJ AGKRT AGMDO AGQXC AGSYK AGUTN AHMBA AHMMS AI. AJEEA ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQC APIBT APJGH AQDSO AQKUS ARIXL ATGXG AVWKF AYOIW BAWUL BAYMD BBNVY BCRHZ BENPR BEYMZ BHONS BHPHI BKEYQ BPHCQ BQDIO BSWAC BTRTY BVRKM BVXVI BZKNY C45 CCPQU CDBKE CGR CS3 CUY CVF DAKXR DIK DILTD E3Z EBS ECM EIF EIHJH EJD EMB EMOBN ENERS EX3 F5P FECEO FHSFR FLUFQ FOEOM FOTVD FQBLK FYUFA GAUVT GJXCC GX1 H13 HCIFZ HMCUK IAO IH2 IHR INH ITC J21 J5H KBUDW KOP KQ8 KSI KSN L7B LID LK8 LSO M1P M7P MBLQV MHKGH N4W NAPCQ NLBLG NOMLY NOYVH NPM NVLIB O9- OAUYM OAWHX OBOKY OCZFY ODMLO OHT OJQWA OJZSN OK1 OPAEJ OVD OWPYF P2P P6G PAFKI PEELM PQQKQ PROAC PSQYO ROX ROZ RUSNO SJN SV3 TEORI TJX TLC TMA TPV TR2 TWZ UDS UKHRP VH1 VXZ W8F WH7 WOW X7M YAYTL YIN YKOAZ YQI YQJ YXANX ZGI ZXP 7X8 ABXZS ADGKP ADNBA AEMQT AFXAL AJBYB AJNCP ALXQX JXSIZ NU- |
| ID | FETCH-LOGICAL-c165t-9ceb8c80d947f4ce35b98a714c76c99c13e9d389621e7db88bf847c92748bdea2 |
| IEDL.DBID | 7X8 |
| ISSN | 0002-9173 |
| IngestDate | Tue Sep 30 22:08:11 EDT 2025 Wed Feb 19 02:40:21 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c165t-9ceb8c80d947f4ce35b98a714c76c99c13e9d389621e7db88bf847c92748bdea2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| PMID | 16830958 |
| PQID | 68628477 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_68628477 pubmed_primary_16830958 |
| PublicationCentury | 2000 |
| PublicationDate | 2006-Jun |
| PublicationDateYYYYMMDD | 2006-06-01 |
| PublicationDate_xml | – month: 06 year: 2006 text: 2006-Jun |
| PublicationDecade | 2000 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | American journal of clinical pathology |
| PublicationTitleAlternate | Am J Clin Pathol |
| PublicationYear | 2006 |
| SSID | ssj0012804 |
| Score | 1.8652071 |
| SecondaryResourceType | review_article |
| Snippet | Although some autoantibodies do not cause hemolysis and their workup is performed routinely, others might lead to life-threatening hemolysis. In the latter... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | S71 |
| SubjectTerms | Anemia, Hemolytic, Autoimmune - diagnosis Anemia, Hemolytic, Autoimmune - therapy Autoantibodies - blood Blood Transfusion Coombs Test Erythrocytes - immunology Humans Pathology, Clinical - methods |
| Title | Laboratory evaluation and transfusion support of patients with autoimmune hemolytic anemia |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/16830958 https://www.proquest.com/docview/68628477 |
| Volume | 125 Suppl |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LSwMxEB6qVfHio77qMwevS3c32U0CgrRiFWxLBcXipSTZLBbsbu1D6L832Qc9iQcvewubzUxmv3xfZgbgmgfMl8QnDjeBwCEBVY70tHbCSPEIkzhkOrN0h_Z6bDDg_QrclLkw9lplGROzQB2lynLkDZvJYCIpvZ18ObZnlNVWiwYaa1DFBsjYC110sNIQfOaSEvyaQwkuRErs8kaz1XdbAXl47lDSwU9vv8PL7DfT3v3fBPdgp4CXqJn7wz5UdFKDzbzh5LIGW91CSj-A905u_nS6RKuS30gkEZpnYHZheTQ0W0wsQkdpjIoSrDNkuVskFvN0ZJNLNPrQ4_Rzad5oRuvxSBzCa_v-5e7RKRotOMoLg7nDlZZMMTfihMZEaRxIzgT1iKKh4lx5WBvDMR76nqaRZEzG5ksVNydaJiMt_CNYT9JEnwCKlBB-ID0pcEhij0sllOLEhArucsxoHa7K1RsaR7bqhJlaupgNy_Wrw3FugOEkr7cx9EJmjBaw0z_HnsF2TpFYluQcqrHZwvoCNtT3fDSbXmb-YZ69fvcHKTnHkA |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Laboratory+evaluation+and+transfusion+support+of+patients+with+autoimmune+hemolytic+anemia&rft.jtitle=American+journal+of+clinical+pathology&rft.au=Reardon%2C+John+E&rft.au=Marques%2C+Marisa+B&rft.date=2006-06-01&rft.issn=0002-9173&rft.volume=125+Suppl&rft.spage=S71&rft_id=info:doi/10.1309%2FABP0B54GQL74L3KW&rft_id=info%3Apmid%2F16830958&rft_id=info%3Apmid%2F16830958&rft.externalDocID=16830958 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-9173&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-9173&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-9173&client=summon |