Clinical course features of atypical demyelinating optic neuritis: case series

Optic neuritis (ON) can often occur at the onset of a demyelinating autoimmune CNS disease or as one of its clinical manifestations. The introduction of novel laboratory techniques, technical advances in magnetic resonance imaging (MRI), electrophysiologic studies, and ocular imaging have significan...

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Veröffentlicht in:Nevrologii͡a︡, neĭropsikhiatrii͡a︡, psikhosomatika Jg. 15; S. 35 - 42
Hauptverfasser: Sheremet, N. L., Eliseeva, D. D., Bryukhov, V. V., Andreeva, N. A., Zhorzholadze, N. V., Murakhovskaya, Yu. K., Kalashnikova, A. K., Zakharova, M. N.
Format: Journal Article
Sprache:Englisch
Russisch
Veröffentlicht: IMA-PRESS LLC 21.08.2023
Schlagworte:
demyelination
magnetic resonance imaging
multiple sclerosis
myelin oligodendrocyte glycoprotein antibody- associated disease
neuromyelitis optica spectrum disorder
optic neuritis
optical coherence tomography
ISSN:2074-2711, 2310-1342
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Zusammenfassung:Optic neuritis (ON) can often occur at the onset of a demyelinating autoimmune CNS disease or as one of its clinical manifestations. The introduction of novel laboratory techniques, technical advances in magnetic resonance imaging (MRI), electrophysiologic studies, and ocular imaging have significantly expanded the spectrum of autoimmune optic neuropathies. Identification of different forms of ON based on clinical and instrumental data can lead to early diagnosis of the underlying neurologic disorder. According to current guidelines, one can distinguish between typical ON, which are mainly associated with multiple sclerosis (MS), and atypical ON, which are the main clinical manifestation of neuromyelitis optica spectrum disorders (NMOSD) and diseases associated with myelin oligodendrocyte glycoprotein antibodies (MOGAD). In this paper, we present four clinical cases of atypical ON at the onset of NMOSD and MOGAD and illustrate the high diagnostic value of a multidisciplinary approach.
ISSN:2074-2711
2310-1342
DOI:10.14412/2074-2711-2023-1S-35-42