Optomyelitis associated with the presence of antibodies to myelin oligodendrocyte glycoprotein. Case report

Antibodies to myelin-oligodendrocyte glycoprotein (anti-MOG-IgG) is a specific biomarker that has been detected in peripheral blood from children with acute multiple encephalomyelitis (ADEM) as well as in adults with aquaporin-4 (AQP4), associated with seronegative opticoneuromyelitis spectrum disea...

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Veröffentlicht in:Consilium medicum (Online) Jg. 24; H. 2; S. 132 - 136
Hauptverfasser: Kalashnikova, Anastasiia K., Sheremet, Nataliia L., Andreeva, Natalia A., Zhorzholadze, Nino V., Ronzina, Irina A., Kaloshina, Anna A.
Format: Journal Article
Sprache:Englisch
Russisch
Veröffentlicht: ZAO "Consilium Medicum" 15.02.2022
Schlagworte:
anti-myelin oligodendrocyte glycoprotein antibodies
multiple sclerosis
myelin oligodendrocyte glycoprotein antibody-associated disease
neuromyelitis optica spectrum disorders
optic neuritis
ISSN:2075-1753, 2542-2170
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Zusammenfassung:Antibodies to myelin-oligodendrocyte glycoprotein (anti-MOG-IgG) is a specific biomarker that has been detected in peripheral blood from children with acute multiple encephalomyelitis (ADEM) as well as in adults with aquaporin-4 (AQP4), associated with seronegative opticoneuromyelitis spectrum disease (NMOSD), brainstem encephalitis, longitudinally disseminated transverse myelitis, and optic neuritis. Most experts now consider MOG-IgG-associated disorder (MOG-AD) an independent disease immunopathogenetically distinct from classical multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG-positive optomyelitis. Isolated, bilateral, and less frequently unilateral OH, with simultaneous or sequential involvement of the eyes, is the most frequent clinical manifestation of MOG-AD. Because of the significant overlap in the clinical and radiological picture, MOG-AD is often misdiagnosed as MS. Timely diagnosis is critical to ensure appropriate treatment. This article describes a clinical case of anti-MOG-IgG encephalomyelitis with late-onset ON initially diagnosed as MS.
ISSN:2075-1753
2542-2170
DOI:10.26442/20751753.2022.2.201391