Preclinical evaluation of antigen-specific B-cell depletion for phospholipase A2 receptor membranous nephropathy with chimeric autoantibody receptor T cells

Phospholipase A2 receptor (PLA2R)-associated membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults, driven by autoantibodies that target PLA2R on kidney podocytes. Antibody-based therapy with rituximab induces broad B-cell depletion but is associated with risks of serious in...

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Veröffentlicht in:	Kidney international
Hauptverfasser:	Altun, Burcin, Zhao, Gexin, Wang, Baomei, Mao, Xuming, Manfredo-Vieira, Silvio, Willis, Elinor, Radaelli, Enrico, Goodman, Emma E, Boesteanu, Alina C, Gill, Saar I, Patel, Darshil R, Wong, Steven, Cottman-Thomas, Ebony, Hogan, Jonathan J, Payne, Aimee S
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 31.10.2025
Schlagworte:	nephrology kidney chimeric antigen receptor autoimmunity cell therapy
ISSN:	1523-1755, 1523-1755
Online-Zugang:	Weitere Angaben
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