13 C hyperpolarization with nitrogen-vacancy centers in micro- and nanodiamonds for sensitive magnetic resonance applications
Nuclear hyperpolarization is a known method to enhance the signal in nuclear magnetic resonance (NMR) by orders of magnitude. The present work addresses the 13 C hyperpolarization in diamond micro- and nanoparticles, using the optically pumped nitrogen-vacancy center (NV) to polarize 13 C spins at r...
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| Vydáno v: | Science advances Ročník 11; číslo 9; s. eadq6836 |
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| Jazyk: | angličtina |
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28.02.2025
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| ISSN: | 2375-2548, 2375-2548 |
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| Abstract | Nuclear hyperpolarization is a known method to enhance the signal in nuclear magnetic resonance (NMR) by orders of magnitude. The present work addresses the 13 C hyperpolarization in diamond micro- and nanoparticles, using the optically pumped nitrogen-vacancy center (NV) to polarize 13 C spins at room temperature. Consequences of the small particle size are mitigated by using a combination of surface treatment improving the 13 C relaxation ( T 1 ) time, as well as that of NV, and applying a technique for NV illumination based on a microphotonic structure. Adjustments to the dynamical nuclear polarization sequence (PulsePol) are performed, as well as slow sample rotation, to improve the NV- 13 C polarization transfer rate. The hyperpolarized 13 C NMR signal is observed in particles of 2-micrometer and 100-nanometer median sizes, with enhancements over the thermal signal (at 0.29-tesla magnetic field) of 1500 and 940, respectively. The present demonstration of room-temperature hyperpolarization anticipates the development of agents based on nanoparticles for sensitive magnetic resonance applications.
Nuclear hyperpolarization of 13 C spins is performed at ambient conditions in micro- and nanodiamonds. |
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| AbstractList | Nuclear hyperpolarization is a known method to enhance the signal in nuclear magnetic resonance (NMR) by orders of magnitude. The present work addresses the 13 C hyperpolarization in diamond micro- and nanoparticles, using the optically pumped nitrogen-vacancy center (NV) to polarize 13 C spins at room temperature. Consequences of the small particle size are mitigated by using a combination of surface treatment improving the 13 C relaxation ( T 1 ) time, as well as that of NV, and applying a technique for NV illumination based on a microphotonic structure. Adjustments to the dynamical nuclear polarization sequence (PulsePol) are performed, as well as slow sample rotation, to improve the NV- 13 C polarization transfer rate. The hyperpolarized 13 C NMR signal is observed in particles of 2-micrometer and 100-nanometer median sizes, with enhancements over the thermal signal (at 0.29-tesla magnetic field) of 1500 and 940, respectively. The present demonstration of room-temperature hyperpolarization anticipates the development of agents based on nanoparticles for sensitive magnetic resonance applications.
Nuclear hyperpolarization of 13 C spins is performed at ambient conditions in micro- and nanodiamonds. Nuclear hyperpolarization is a known method to enhance the signal in nuclear magnetic resonance (NMR) by orders of magnitude. The present work addresses the C hyperpolarization in diamond micro- and nanoparticles, using the optically pumped nitrogen-vacancy center (NV) to polarize C spins at room temperature. Consequences of the small particle size are mitigated by using a combination of surface treatment improving the C relaxation ( ) time, as well as that of NV, and applying a technique for NV illumination based on a microphotonic structure. Adjustments to the dynamical nuclear polarization sequence (PulsePol) are performed, as well as slow sample rotation, to improve the NV- C polarization transfer rate. The hyperpolarized C NMR signal is observed in particles of 2-micrometer and 100-nanometer median sizes, with enhancements over the thermal signal (at 0.29-tesla magnetic field) of 1500 and 940, respectively. The present demonstration of room-temperature hyperpolarization anticipates the development of agents based on nanoparticles for sensitive magnetic resonance applications. |
| Author | Nothelfer, Steffen Knolle, Wolfgang Jentgens, Christian Jelezko, Fedor Plenio, Martin B. Blinder, Rémi Korzeczek, Martin Laube, Christian Mindarava, Yuliya Marshall, Alastair Glöckler, Felix Kienle, Alwin |
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