DINAMIKA MINERAL'NOY PLOTNOSTI KOSTI U RETsIPIENTOV POSLE PERESADKI PEChENI

Axial and periferal bone mineral density (BMD) was estimated by DXA twice within 1-47 months in 16 patients following orthotopic liver transplantation (OLT). Osteoporosis and osteopenia of lumbar spine and hip were identified in the first examination of all 9 recipients (group 1) with primary biliar...

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Veröffentlicht in:Osteoporoz i osteopatii Jg. 12; H. 2; S. 2 - 4
Hauptverfasser: Ermakova, I P, Moysyuk, Ya G, Buzulina, V P, Koliashvili, T K, Yaroshenko, E B, Kornilov, M N, Pronchenko, I A, Shmerko, N P
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Endocrinology Research Centre 15.08.2009
Schlagworte:
минеральная плотность костной ткани
ортотопическая трансплантация печени
первичный билиарный цирроз
хронические вирусные гепатиты
ISSN:2072-2680, 2311-0716
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Zusammenfassung:Axial and periferal bone mineral density (BMD) was estimated by DXA twice within 1-47 months in 16 patients following orthotopic liver transplantation (OLT). Osteoporosis and osteopenia of lumbar spine and hip were identified in the first examination of all 9 recipients (group 1) with primary biliary cirrhosis (PBC) and in 5 out of 7 (71%) patients with viral hepatitic cirrhosis (group 2). Recipients which were firstly examined within 1-7 months following OLT (subgroups 1A, 2A) through 9±2.8 months showed in 1A axial BMD elevation (on 20.7+13.2% ; P=0.024) and in 2A axial so as hip BMD elevation (on 10.5+2.7%;P=0.001 and 8.1+5.9%;P< 0.05). Recipients which were examined later 18 months after OLT demonstrated no increase in BMD (subgroups 1B and 2B). Moreover two of them with PBC showed decrease in BMD, probably, as a result of transplant dysfunction and immunosuppression with glucocorticoids.
ISSN:2072-2680
2311-0716
DOI:10.14341/osteo200922-4