Determination of Amino Acids' p K a : Importance of Cavity Scaling within Implicit Solvation Models and Choice of DFT Functionals

Protonation states of molecules significantly influence the thermodynamics and kinetics of chemical reactions. This is especially important in biochemical processes, where appropriate protonation states of amino acids control the exo/endoergicity of practically all biochemical cycles. This paper is...

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Bibliographic Details
Published in:The journal of physical chemistry. B Vol. 128; no. 7; p. 1627
Main Authors: Šebesta, Filip, Sovová, Žofie, Burda, Jaroslav V
Format: Journal Article
Language:English
Published: United States 22.02.2024
ISSN:1520-5207
Online Access:Get more information
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