ASSESSMENT OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I CHAIN-RELATED A (MICA) MOLECULE LEVELS IN INTENSIVE CARE UNIT PATIENTS WITH CLOSTRIDIAL INFECTION

Background. The genes of the MIC locus discovered at the end of the 20th century are characterized by high polymorphism. They play an important role in the processes of intercellular interaction, participate in the implementation of innate and adaptive immunity reactions as ligands for the NKG2D rec...

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Published in:Zhurnal Grodnenskogo gosudarstvennogo medit͡s︡inskogo universiteta Vol. 23; no. 4; pp. 342 - 346
Main Authors: Lemesh, A. V., Yakubtsevich, R. E., Shulga, A. V.
Format: Journal Article
Language:English
Published: 01.09.2025
ISSN:2221-8785, 2413-0109
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Abstract Background. The genes of the MIC locus discovered at the end of the 20th century are characterized by high polymorphism. They play an important role in the processes of intercellular interaction, participate in the implementation of innate and adaptive immunity reactions as ligands for the NKG2D receptors expressed on various subpopulations of T-lymphocytes. MICA can be released from the surface of tumor and infected cells after proteolytic cleavage, yielding soluble MICA (sMICA) in serum. MICA is normally detected in low amounts on the surface of endothelial cells fibroblasts monocytes syncytiotrophoblast and epithelial cells especially in the gastrointestinal tract. However this expression increases during stress conditions. Objective. To determine the nature of MICA expression in the intestinal mucosa using immunohistochemistry, as well as the level of sMICA in the blood serum using enzyme immunoassay in patients of the Anesthesiology and Intensive Care Units with clostridial infection induced by antibacterial drugs of the carbapenem group. Results. When assessing the marker expression in biopsy material of patients with clostridial infection and a group without colon pathology, a more pronounced reaction in the mucosa was observed in patients with clostridial infection. When analyzing sMICA indicators, the following results were obtained: the median value was 35.4 ng / ml; 95% confidence interval 105.6-162.7; 25-75% percentile 25.9-66.1. Conclusions. The level of MICA in the blood serum, as well as in the colonic mucosa, in patients with clostridial infection of the AIC units increases when compared with the control group.
AbstractList Background. The genes of the MIC locus discovered at the end of the 20th century are characterized by high polymorphism. They play an important role in the processes of intercellular interaction, participate in the implementation of innate and adaptive immunity reactions as ligands for the NKG2D receptors expressed on various subpopulations of T-lymphocytes. MICA can be released from the surface of tumor and infected cells after proteolytic cleavage, yielding soluble MICA (sMICA) in serum. MICA is normally detected in low amounts on the surface of endothelial cells fibroblasts monocytes syncytiotrophoblast and epithelial cells especially in the gastrointestinal tract. However this expression increases during stress conditions. Objective. To determine the nature of MICA expression in the intestinal mucosa using immunohistochemistry, as well as the level of sMICA in the blood serum using enzyme immunoassay in patients of the Anesthesiology and Intensive Care Units with clostridial infection induced by antibacterial drugs of the carbapenem group. Results. When assessing the marker expression in biopsy material of patients with clostridial infection and a group without colon pathology, a more pronounced reaction in the mucosa was observed in patients with clostridial infection. When analyzing sMICA indicators, the following results were obtained: the median value was 35.4 ng / ml; 95% confidence interval 105.6-162.7; 25-75% percentile 25.9-66.1. Conclusions. The level of MICA in the blood serum, as well as in the colonic mucosa, in patients with clostridial infection of the AIC units increases when compared with the control group.
Author Shulga, A. V.
Lemesh, A. V.
Yakubtsevich, R. E.
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CorporateAuthor Grodno State Medical University, Grodno, Belarus
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Title ASSESSMENT OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I CHAIN-RELATED A (MICA) MOLECULE LEVELS IN INTENSIVE CARE UNIT PATIENTS WITH CLOSTRIDIAL INFECTION
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